Results 21 to 30 of about 695,037 (266)

Elimination of hepatitis C virus from hepatocytes by a selective activation of therapeutic molecules. [PDF]

PLoS ONE, 2011
To eliminate hepatitis C virus (HCV) from infected hepatocytes, we generated two therapeutic molecules specifically activated in cells infected with HCV.
Xiaoyu Wen, Takayuki Abe, Hiroshi Kukihara, Shuhei Taguwa, Yoshio Mori, Hideki Tani, Nobuyuki Kato, Tetsuro Suzuki, Masashi Tatsumi, Kohji Moriishi, Yoshiharu Matsuura   +10 more
doaj   +1 more source

Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

Nature Communications, 2016
Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for ...
Nari Kim, Min-Jung Kim, Pil Soo Sung, Yong Chul Bae, Eui-Cheol Shin, Joo-Yeon Yoo   +5 more
doaj   +1 more source

Hepatitis C Viral Replication Complex

Viruses, 2021
The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release.
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
doaj   +1 more source

The selective autophagic degradation of avian metapneumovirus subgroup C M2-2 protein via SQSTM1 suppresses viral replication

Autophagy Reports
Avian metapneumovirus subgroup C (aMPV/C) is an emerging pathogen that causes acute respiratory infection in chickens and turkeys. Sequestosome 1 (SQSTM1), a selective autophagy receptor, regulates cellular activity or viral replication by recognizing ...
Lei Hou, Jinshuo Guo, Jianwei Zhou, Jue Liu   +3 more
doaj   +1 more source

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.

PLoS Biology, 2019
Accurate genome duplication underlies genetic homeostasis. Metazoan Mdm2 binding protein (MTBP) forms a main regulatory platform for origin firing together with Treslin/TICRR and TopBP1 (Topoisomerase II binding protein 1 (TopBP1)-interacting replication
Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P Ponting, Ambrosius P Snijders, Regina Feederle, Aloys Schepers, Dominik Boos   +8 more
doaj   +1 more source

Interactome Profiling of N-Terminus-Truncated NS1 Protein of Influenza A Virus Reveals Role of 14-3-3γ in Virus Replication

Pathogens, 2022
Influenza A virus is transmitted through a respiratory route and has caused several pandemics throughout history. The NS1 protein of influenza A virus, which consists of an N-terminal RNA-binding domain and a C-terminal effector domain, is considered one
Rei-Lin Kuo, Ee-Hong Tam, Chian-Huey Woung, Chu-Mi Hung, Hao-Ping Liu, Helene Minyi Liu, Chih-Ching Wu   +6 more
doaj   +1 more source

Generation of H9 T-cells stably expressing a membrane-bound form of the cytoplasmic tail of the Env-glycoprotein: lack of transcomplementation of defective HIV-1 virions encoding C-terminally truncated Env

Retrovirology, 2006
H9-T-cells do not support the replication of mutant HIV-1 encoding Env protein lacking its long cytoplasmic C-terminal domain (Env-CT). Here we describe the generation of a H9-T-cell population constitutively expressing the HIV-1 Env-CT protein domain ...
Bosch Valerie, Pfeiffer Tanya, Holtkotte Denise   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation.

PLoS ONE, 2019
Hepatitis C virus (HCV) replication involves many viral and host factors. Host factor SPRY domain- and SOCS box-containing protein 2(SPSB2) belongs to SPSB family, and it recruits target proteins by the SPRY domain and forms E3 ubiquitin ligase complexes
Mingzhen Wang, Yu Wang, Yuehong Liu, Hailong Wang, Xiu Xin, Jiadai Li, Yao Hao, Lingling Han, Fang Yu, Congyi Zheng, Chao Shen   +10 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source