Results 91 to 100 of about 334,121 (353)
Optimizing periodicity and polymodality in noise-induced genetic oscillators [PDF]
, 2011 Many cellular functions are based on the rhythmic organization of biological processes into self-repeating cascades of events. Some of these periodic processes, such as the cell cycles of several species, exhibit conspicuous irregularities in the form of
A. Sveiczer +6 more
core +3 more sources
The TetR Family of Transcriptional Repressors [PDF]
Microbiology and Molecular Biology Reviews, 2005 SUMMARYWe have developed a general profile for the proteins of the TetR family of repressors. The stretch that best defines the profile of this family is made up of 47 amino acid residues that correspond to the helix-turn-helix DNA binding motif and adjacent regions in the three-dimensional structures of TetR, QacR, CprB, and EthR, four family members ...
Ramos, Juan L. +8 more
openaire +4 more sources
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Spatiotemporal expressions reflecting topological classes of repressor networks [PDF]
arXiv, 2017 A family of repressor networks is proposed as a simple model of gene regulatory networks. We analytically show three topological classes of the repressor networks, each of which exhibits distinctly growing complexity of spatiotemporal expressions starting from nearly homogeneous states.
arxiv
Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and post-transcriptional regulations [PDF]
, 2014 Mixed feedback loops combining transcriptional and post-transcriptional regulations are common in cellular regulatory networks. They consist of two genes, encoding a transcription factor and a small non-coding RNA (sRNA), which mutually regulate each other's expression.
arxiv +1 more source
Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]
, 2020 Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes +25 more
core
First-principles calculation of DNA looping in tethered particle experiments [PDF]
, 2008 We calculate the probability of DNA loop formation mediated by regulatory proteins such as Lac repressor (LacI), using a mathematical model of DNA elasticity. Our model is adapted to calculating quantities directly observable in Tethered Particle Motion (
Beausang, John F. +4 more
core +4 more sources
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Effect of DNA looping on the induction kinetics of the lac operon [PDF]
arXiv, 2007 The induction of the lac operon follows cooperative kinetics.The first mechanistic model of these kinetics is the de facto standard in the modeling literature (Yagil & Yagil, Biophys J, 11, 11-27, 1971). Yet, subsequent studies have shown that the model is based on incorrect assumptions.
arxiv
Multiphasic denaturation of the λ repressor by urea and its implications for the repressor structure [PDF]
European Journal of Biochemistry, 1992 Urea denaturation of the λ repressor has been studied by fluorescence and circular dichroic spectroscopies. Three phases of denaturation could be detected which we have assigned to part of the C‐terminal domain, N‐terminal domain and subunit dissociation coupled with further denaturation of the rest of the C‐terminal domain at increasing urea ...
Bhabatarak Bhattacharyya +4 more
openaire +3 more sources