Results 91 to 100 of about 496,166 (395)

Targeting MYH9 represses USP14-mediated NAP1L1 deubiquitination and cell proliferation in glioma [PDF]

, 2023
Zigui Chen, Xin Yan, Changfeng Miao, Longyang Liu, Su Liu, Ying Xia, Weiyi Fang, Dandan Zheng, Qisheng Luo   +8 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Regulatory control and the costs and benefits of biochemical noise [PDF]

, 2008
Experiments in recent years have vividly demonstrated that gene expression can be highly stochastic. How protein concentration fluctuations affect the growth rate of a population of cells, is, however, a wide open question.
A Bar-Even, A Becskei, A Sigal, A Wagner, Aviv Regev, DM Wolf, DS Falconer, DT Gillespie, DW Austin, E Dekel, E Dekel, E Kussell, E Kussell, E Levine, E Ziv, EM Ozbudak, G Yagil, H Risken, J Elf, J Paulsson, J Seger, J Yu, JL Ingraham, JM Pedraza, JM Raser, JR Sadler, JRS Newman, L Cai, M Kaern, M Thattai, MA Savageau, MA Savageau, MB Elowitz, MB Elowitz, MW van der Woude, N Rosenfeld, NQ Balaban, P Kolkhof, PB Detwiler, Pieter Rein ten Wolde, S Gavrilets, S Tănase-Nicola, Sorin Tănase-Nicola, T Kalisky, T Lu, T Shibata, W Gilbert, X Zhang   +47 more
core   +5 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [PDF]

, 2007
Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network.
Davidson, Eric H., Giles, Shane, Ji, Hongkai, Longabaugh, William J. R., McCuine, Scott, McMahon, Andrew P., Tenzen, Toyoaki, Vokes, Steven A., Wong, Wing H., Zhong, Sheng   +9 more
core   +2 more sources

Cytokinin Response Factor 9 Represses Cytokinin Responses in Flower Development [PDF]

, 2023
Christine Swinka, Eva Hellmann, Paul J. Zwack, Ramya Banda, Aaron M. Rashotte, Alexander Heyl   +5 more
openalex   +1 more source

Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains

Nature Communications, 2012
Transcription activator-like effectors are sequence-specific DNA-binding proteins that harbour modular, repetitive DNA-binding domains. Transcription activator-like effectors have enabled the creation of customizable designer transcriptional factors and ...
Le Cong, R. Zhou, Yu-chi Kuo, Margaret M Cunniff, Feng Zhang   +4 more
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Subspecialization of R2R3-MYB repressors for anthocyanin and proanthocyanidin regulation in forage legumes

Frontiers in Plant Science, 2015
The synthesis of anthocyanin pigments and proanthocyanidins (condensed tannins) is regulated by MYB-bHLH-WDR (MBW) transcription factor complexes in all angiosperms studied to date. Tr-MYB133 and Tr-MYB134 were isolated from T.
Nick W Albert, Nick W Albert
doaj   +1 more source

miR-409-3p represses Cited2 to refine neocortical layer V projection neuron identity [PDF]

, 2022
Nikolaus R. Wagner, Ashis Sinha, Verl Siththanandan, Angelica Kowalchuk, Jessica L. MacDonald, Suzanne Tharin   +5 more
openalex   +1 more source