Results 101 to 110 of about 334,121 (353)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Ets-2 Acts As a Transcriptional Repressor of the Human Immunodeficiency Virus Type 1 through Binding to a Repressor–Activator Target Sequence of 5′-LTR

Frontiers in Immunology, 2018
HIV-1 is transcriptionally active in activated T helper (Th)-cells and inactive in naive or resting memory Th-cells. Ets-2 is a preinduction transcriptional repressor of the IL-2 gene in naive Th-cells and a candidate transcriptional repressor of HIV-1 ...
Ioannis Panagoulias, Fotios Karagiannis, Ioanna Aggeletopoulou, Tassos Georgakopoulos, Christos P. Argyropoulos, Karolina Akinosoglou, Charalambos Gogos, Athanasios Skoutelis, Athanasia Mouzaki   +8 more
doaj   +1 more source

Noise-based switches and amplifiers for gene expression

, 2000
The regulation of cellular function is often controlled at the level of gene transcription. Such genetic regulation usually consists of interacting networks, whereby gene products from a single network can act to control their own expression or the ...
Asbury, Dickson, Gardner, Harada, Johnson, Johnson, Keller, Liu, McAdams, McAdams, Ptashne, von Hippel, Wolf, Xie, Yuh   +14 more
core   +2 more sources

Strong negative self regulation of Prokaryotic transcription factors increases the intrinsic noise of protein expression [PDF]

, 2008
Background Many prokaryotic transcription factors repress their own transcription. It is often asserted that such regulation enables a cell to homeostatically maintain protein abundance.
A Bar-Even, A Becskei, A de la Hoz, A Kierzek, C Cox, D Austin, Dafyd J Jenkins, Dov J Stekel, E Ozdubak, F Neidhardt, G Shinar, H El-Samad, I Keseler, J Paulsson, J Plumbridge, K Kostelidou, L Bingle, L Cai, M Elowitz, M Gibson, M Keeling, M Koern, M Samoilov, M Simpson, M Simpson, M Thattai, M Wall, N Rosenfeld, P Chivers, P Swain, Q Wang, R Rolfes, S Hooshangi, S Reichheld, T Kepler, Y Dublanche   +35 more
core   +4 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Increased skin conductance responses and neural activity during fear conditioning are associated with a repressive coping style

Frontiers in Behavioral Neuroscience, 2015
The investigation of individual differences in coping styles in response to fear conditioning is an important issue for a better understanding of the etiology and treatment of psychiatric disorders.
Tim eKlucken, Onno eKruse, Jan eSchweckendiek, Rudolf eStark   +3 more
doaj   +1 more source

NF-Y recruits both transcription activator and repressor to modulate tissue- and developmental stage-specific expression of human γ-globin gene. [PDF]

PLoS ONE, 2012
The human embryonic, fetal and adult β-like globin genes provide a paradigm for tissue- and developmental stage-specific gene regulation. The fetal γ-globin gene is expressed in fetal erythroid cells but is repressed in adult erythroid cells.
Xingguo Zhu, Yongchao Wang, Wenhu Pi, Hui Liu, Amittha Wickrema, Dorothy Tuan   +5 more
doaj   +1 more source

Computational Limitations of First-Order Repressor Systems [PDF]

arXiv, 2016
Almost all current approaches for engineering modular logic components in synthetic biology use first-order regulators, including most CRISPR/CAS, TAL, zinc finger, and RNA interference systems. Many practitioners understand intuitively that second and higher order binding is necessary for scalability, and this is easy to show for single-input single ...
arxiv  

Coarse-Grained Model of Entropic Allostery [PDF]

, 2003
Many signalling functions in molecular biology require proteins bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via a conformational change in response to the ligand binding.
arxiv   +1 more source