Results 181 to 190 of about 355,752 (283)

Sulphate esters as de-repressors of arylsulphatase formation and the problem of sulphate ester utilization by Pseudomonas C12B [PDF]

, 1977
John W. Fitzgerald, Marsha E. Cline, Frederick A. Rose   +2 more
openalex   +1 more source

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

Identification of Mycobacterium tuberculosis transcriptional repressor EthR inhibitors: Shape-based search and machine learning studies

Heliyon
Tuberculosis has been a challenge to the world since prehistoric times, and with the advent of drug-resistant strains, it has become more challenging to treat this infection.
Rupesh V. Chikhale, Gaber E. Eldesoky, Mahima Sudhir Kolpe, Vikramsinh Sardarsinh Suryawanshi, Pritee Chunarkar Patil, Shovonlal Bhowmick   +5 more
doaj  

Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences. [PDF]

Int J Mol Sci
Cattini PA, Jin Y.
europepmc   +1 more source

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

Advanced Science, EarlyView.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu, Amarnath Marudamuthu, Khadija Kakar, Hamida Hamida, Shruthi Thada, Rohan Gupta, Kiesha Wilson, Taylor Carter, Yin Zhong, Archana Saxena, Xiaoming Yang, Narendra Singh, Philip Brandon Busbee, Jie Li, Monica Garcia‐Buitrago, Prakash Nagarkatti, Mitzi Nagarkatti   +16 more
wiley   +1 more source

Repressors: Translational Restarts [PDF]

, 1972

openalex   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

Production of Vitamin B₁₂ in <i>Escherichia coli</i> Using a Thermal Switch to Control Pathway Genes. [PDF]

J Microbiol Biotechnol
Kong K, Chen F, Fang H, Jiang P, Zhao X, Zhang J, Dong H, Jin H, Zhang D.   +8 more
europepmc   +1 more source

Isolation and Chemical Properties of a Repressible Acid Phosphatase in Neurospora crassa

, 1971
Maryce M. Jacobs, Joseph F. Nyc, Douglas M. Brown   +2 more
openalex   +1 more source

Repressors at the molecular level [PDF]

, 1974
Stephen Neidle
openalex   +1 more source