Results 191 to 200 of about 355,752 (283)

Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion

Advanced Science, EarlyView.
This study identifies Globo H ceramide (GHCer) as a novel immune checkpoint molecule that suppresses the activation of conventional T lymphocytes while promoting the differentiation and function of regulatory T cells. The immunosuppressive effects of GHCer are mediated through the activation of the A2AR/cAMP/PKA pathway, which involves its interactions
Jing‐Yan Cheng, Hsiu‐Hui Tsai, Jung‐Tung Hung, Tsai‐Hsien Hung, Chun‐Cheng Lin, Chien‐Wei Lee, Zi‐Chi Lo, Jing‐Rong Huang, Shih‐Pin Chiou, Yenlin Huang, Shih‐Hsiang Chen, Chun‐Nan Yeh, John Yu, Alice L. Yu   +13 more
wiley   +1 more source

Feedback-delay dependence of the stability of cluster periodic orbits in populations of degrade-and-fire oscillators with common activator. [PDF]

J Math Biol
Fernandez B, Tanzi M.
europepmc   +1 more source

Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor. [PDF]

, 1989
Ulrich Deuschle, Rainer Pepperkok, Fang Wang, Thomas J. Giordano, William T. McAllister, W. Ansorge, H Bujard   +6 more
openalex   +1 more source

JA‐Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8‐SlWRKY57‐SlAVT6s Module in Tomato

Advanced Science, EarlyView.
This study elucidates a novel SlJAZ8‐SlWRKY57‐SlAVT6A/SlAVT6B module that effectively channels metabolic flux from primary to secondary metabolism, impacting plant growth, development, and resistance. Two novel vacuolar amino acid exporters, SlAVT6A and SlAVT6B, fine‐tunes trichomes, terpenes, and gibberellins, bolstering spider mite resistance.
Yingchen Hao, Xiaolong Wang, Langchen Guo, Lijun Xiang, Enxi Luo, Peng Cao, Penghui Liu, Yue Zhong, Chun Li, Jun Lai, Jun Yang, Shouchuang Wang   +11 more
wiley   +1 more source

Deciphering regulatory architectures of bacterial promoters from synthetic expression patterns. [PDF]

PLoS Comput Biol
Pan RW, Röschinger T, Faizi K, Garcia HG, Phillips R.   +4 more
europepmc   +1 more source

Control of Transcription of the Repressor Gene in Bacteriophage Lambda

, 1970
Stephen F. Heinemann, Willard G. Spiegelman   +1 more
openalex   +1 more source

DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor. [PDF]

, 1988
Gerald B. Koudelka, Pehr B. Harbury, Stephen C. Harrison, Mark Ptashne   +3 more
openalex   +1 more source

From Code to Life: The AI‐Driven Revolution in Genome Editing

Advanced Science, EarlyView.
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li, Wasi Ullah Khan, Genxiang Bai, Chao Dong, Jungang Wang, Youpeng Zhang, Chong Wang, Hongbin Zhang, Wenyi Wang, Ming Luo, Fei Chen   +10 more
wiley   +1 more source

REST Is Restless in Neuronal and Non-Neuronal Virus Infections: An In Silico Analysis-Based Perspective. [PDF]

Viruses
Pillai VS, Ravindran S, Krishna G, Abhinand CS, Nelson-Sathi S, Veettil MV.   +5 more
europepmc   +1 more source

Chemical modification of lactose repressor protein using N-substituted maleimides.

, 1979
R. Dale Brown, Kathleen S. Matthews
openalex   +1 more source