Results 201 to 210 of about 355,752 (283)

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

Advanced Science, EarlyView.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen, Junyuan Xue, Ziying Wang, Jinyuan Sun, Yinglu Cui, Tong Zhu, Huaiyi Yang, Ming Li, Bian Wu   +8 more
wiley   +1 more source

Development of a Transcriptional Biosensor for Hydrogen Sulfide That Functions under Aerobic and Anaerobic Conditions. [PDF]

ACS Synth Biol
Fernez MT, Hegde S, Hayes JA, Hoyt KO, Carrier RL, Woolston BM.   +5 more
europepmc   +1 more source

In vitro synthesis of repressible yeast acid phosphatase: identification of multiple mRNAs and products. [PDF]

, 1980
Keith A. Bostian, Joan M. Lemire, L. Edward Cannon, H. O. Halvorson   +3 more
openalex   +1 more source

GbSER02 Interacts With GhVOZ1 to Promote Fiber Elongation by Modulating Gibberellin Synthesis in Cotton

Advanced Science, EarlyView.
GbSER02 with a single base change (SNP517G) encodes normal serpin protein and interacts with transcription factor VOZ1 to alleviate the repression of VOZ1 on GA3ox1 and promote GA3 biosynthesis. Further, GA3 induces the expression of cell wall loosening‐related genes and decreases flavonoid content, ultimately facilitating fiber cell elongation in ...
Hao Jia, Dongmei Zhang, Qishen Gu, Yanbin Li, Jing Li, Wannian Li, Zhengwen Sun, Huifeng Ke, Jun Yang, Liqiang Wu, Yan Zhang, Zhiying Ma, Xingfen Wang   +12 more
wiley   +1 more source

Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins. [PDF]

J Mol Recognit
Amarasiri HADB, Arachchige D, Vince MJK, Holub JM.   +3 more
europepmc   +1 more source

Activity changes in lac repressor with cysteine oxidation.

, 1979
Susan P. Manly, Kathleen S. Matthews
openalex   +1 more source

lac Repressor blocks transcribing RNA polymerase and terminates transcription. [PDF]

, 1986
Ulrich Deuschle, Reiner Gentz, Hermann Bujard   +2 more
openalex   +1 more source

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

Enhancement of Sensitivity in Aggregation-Based Whole-Cell Arsenite Sensor Utilizing Arsenic Metabolism Regulation. [PDF]

ACS Omega
Abe S, Ayuba R, Ouchi K, Tanaka YK, Fujimoto A, Kitamura A, Ogra Y, Kimura Y, Umeno D, Kawai-Noma S.   +9 more
europepmc   +1 more source

Two helix DNA binding motif of CAP found inlacrepressor andgalrepressor [PDF]

, 1982
Irene T. Weber, David McKay, R.A. Steitz
openalex   +1 more source