Results 211 to 220 of about 382,695 (354)

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

Derivatization of pBACpAK entrapment vectors for enhanced mobile genetic element transposition detection in multidrug-resistant Escherichia coli. [PDF]

Access Microbiol
Tansirichaiya S, Leartsiwawinyu W, Thanawan N, Goodman RN, Tribuddharat C, Roberts AP.   +5 more
europepmc   +1 more source

The Location of the Repressor Binding Sites in the lac Operon

, 1974
William S. Reznikoff, Robert B. Winter, Carolyn Katovich Hurley   +2 more
openalex   +1 more source

Structural studies of the Cro repressor protein from bacteriophage λ [PDF]

, 1981
Brian W. Matthews, W. French Anderson, D.H. Ohlendorf, Yoshinori Takeda   +3 more
openalex   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Bifaceted functions of histone methyltransferases. [PDF]

Epigenomics
Akhtar J, Saloura V.
europepmc   +1 more source

DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor. [PDF]

, 1988
Gerald B. Koudelka, Pehr B. Harbury, Stephen C. Harrison, Mark Ptashne   +3 more
openalex   +1 more source

Polyadenylation Complex CFII Recognizes Downstream Cis‐element for Pre‐mRNA Polyadenylation Through Interaction with an RNA‐Binding Protein in Arabidopsis

Advanced Science, EarlyView.
This study investigates the cis‐element in pre‐mRNA recognized by the polyadenylation CFII complex. It elucidates how the CFII complex recognizes the consensus cis‐element downstream of the poly(A) site for pre‐mRNA alternative polyadenylation. This comprehensive research provides novel insights into the interaction between 3′ end processing complexes ...
Ying Cao, Ying Guo, Zhibo Yu, Huajian Nie, Jing Yang, Dingfu Qiu, Qiyu Li, Xu Xin, Chang Cheng, Yan Li, Xudong Shang, Yuling Jiao, Qingshun Quinn Li, Ligeng Ma   +13 more
wiley   +1 more source

Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves. [PDF]

Mol Med Rep
Suzuki T, Naito K, Kubota D, Ueno Y, Negishi-Koga T, Yamamoto Y, Kawakita S, Imazu N, Kawamura K, Hattori N, Ishijima M.   +10 more
europepmc   +1 more source

Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor. [PDF]

, 1989
Ulrich Deuschle, Rainer Pepperkok, Fang Wang, Thomas J. Giordano, William T. McAllister, W. Ansorge, H Bujard   +6 more
openalex   +1 more source