Results 211 to 220 of about 334,121 (353)

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

open access: yesAdvanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

open access: yesAdvanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan   +8 more
wiley   +1 more source

Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging. [PDF]

open access: yesMol Med Rep
Kawakita S   +10 more
europepmc   +1 more source

LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis

open access: yesAdvanced Science, EarlyView.
A non‐invasive and safe physical therapy, low‐intensity pulsed ultrasound (LIPUS) can alleviate osteoarthritis. This study dynamically “visualizes” the invisible mechanical stimuli of LIPUS on living chondrocytes by fluorescence imaging technology in the form of calcium oscillations, confirming LIPUS maintains cartilage homeostasis by promoting ...
Mengtong Guan   +12 more
wiley   +1 more source

Identification of Mycobacterium tuberculosis transcriptional repressor EthR inhibitors: Shape-based search and machine learning studies

open access: yesHeliyon
Tuberculosis has been a challenge to the world since prehistoric times, and with the advent of drug-resistant strains, it has become more challenging to treat this infection.
Rupesh V. Chikhale   +5 more
doaj  

Activity changes in lac repressor with cysteine oxidation.

open access: hybrid, 1979
Susan P. Manly, Kathleen S. Matthews
openalex   +1 more source

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