Results 231 to 240 of about 496,166 (395)

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Synthetic Biology Strategies for Activating Cryptic BGCs in <i>Streptomyces</i>: Engineering Native and Synthetic Promoters for Antibiotic Discovery. [PDF]

ACS Omega
Shil R, Pattapulavar V, Ramanujam S, Subburaj S, Christopher JG.   +4 more
europepmc   +1 more source

Identification of the gene transcription repressor domain of Gli3

, 2008
Robert Tsanev, Piret Tiigimägi, Piret Michelson, Madis Metsis, Torben Østerlund, Priit Kogerman   +5 more
openalex   +1 more source

Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination [PDF]

, 2009
Heiko Schober, Helder Ferreira, Véronique Kalck, Lutz R. Gehlen, Susan M. Gasser   +4 more
openalex   +1 more source

IP-MS, MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes

, 2023
Yoshiho Ikeuchi, Azad Bonni, Harrison W. Gabel   +2 more
openalex   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Greening the Solid-Phase Peptide Synthesis of the First Bicyclic Analogue of the Arc Repressor and Its Binding to DNA. [PDF]

J Org Chem
Procino E, Bouzada D, D'Ingiullo S, Marinaccio L, Zhukov I, Stefanucci A, Mollica A.   +6 more
europepmc   +1 more source

PTEN Represses RNA Polymerase III-Dependent Transcription by Targeting the TFIIIB Complex

, 2008
Annette Woiwode, Sandra Johnson, Shuping Zhong, Cheng Zhang, Robert G. Roeder, Martin Teichmann, Deborah L. Johnson   +6 more
openalex   +1 more source

Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed: Figure 1. [PDF]

, 2003
David J. Waxman, John L. Celenza
openalex   +1 more source

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source