Results 231 to 240 of about 355,752 (283)

Novel mutations in the <i>marR</i> gene (<i>MAB_2648c</i>) modify nitroxoline activity in <i>Mycobacterium abscessus</i>. [PDF]

Antimicrob Agents Chemother
Xu P, Li Y, Xu B, Cao D, Dong X, Xiang Y, Jiang X, Yuan X, Qiu Y, Zhang Y.   +9 more
europepmc   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
wiley   +1 more source

The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors. [PDF]

Sci Rep
Soukar I, Fisher RJ, Bhagavatula S, Collard M, Cole PA, Alani RM.   +5 more
europepmc   +1 more source

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

Advanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang, Yan Chun, Fan Zhang, Tingting Guo, Mengmeng Ren, Jinfeng Zhao, Shoujiang Yuan, Wensheng Wang, Yunhai Li, Xueyong Li   +9 more
wiley   +1 more source

Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation. [PDF]

iScience
Song W, Ovcharenko I.
europepmc   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

Repressor elements provide insights into tissue development and phenotypes in pigs. [PDF]

Zool Res
Zhang YD, Guo C, Liu H, Gao Y, Tan Y, Niu L, Wang L, Wang L, Irwin DM, Hou C, Zhou ZY, Zhang YP.   +11 more
europepmc   +1 more source

Nucleotide sequence binding specificity of the LexA repressor of Escherichia coli K-12

, 1985
Kenneth F. Wertman, David W. Mount
openalex   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis. [PDF]

Nat Genet
Lim B, Kamal A, Gomez Ramos B, Adrian Segarra JM, Ibarra IL, Dignas L, Kindinger T, Volz K, Rahbari M, Rahbari N, Poisel E, Kafetzopoulou K, Böse L, Breinig M, Heide D, Gallage S, Barragan Avila JE, Wiethoff H, Berest I, Schnabellehner S, Schneider M, Becker J, Helm D, Grimm D, Mäkinen T, Tschaharganeh DF, Heikenwalder M, Zaugg JB, Mall M.   +28 more
europepmc   +1 more source