Results 91 to 100 of about 6,797,208 (350)

Light-harvesting chlorophyll a/b-binding proteins, positively involved in abscisic acid signalling, require a transcription repressor, WRKY40, to balance their function

Journal of Experimental Botany, 2013
The light-harvesting chlorophyll a/b-binding (LHCB) proteins are the apoproteins of the light-harvesting complex of photosystem II. In the present study, we observed that downregulation of any of the six LHCB genes resulted in abscisic acid (ABA ...
Rui Liu, Yan-Hong Xu, Shang-Chuan Jiang, Kai Lu, Yan-Fen Lu, Xiu-Jing Feng, Zhen Wu, Shan Liang, Yongtao Yu, Xiao-fang Wang, Da-Peng Zhang   +10 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Calculating Biological Behaviors of Epigenetic States in Phage lambda Life Cycle [PDF]

, 2004
Gene regulatory network of lambda phage is one the best studied model systems in molecular biology. More 50 years of experimental study has provided a tremendous amount of data at all levels: physics, chemistry, DNA, protein, and function.
Ao, P., Hood, L., Yin, L., Zhu, X. -M.
core   +1 more source

Analysis of Rice Proteins with DLN Repressor Motif/S [PDF]

International Journal of Molecular Sciences, 2019
Transcriptional regulation includes both activation and repression of downstream genes. In plants, a well-established class of repressors are proteins with an ERF-associated amphiphilic repression/EAR domain. They contain either DLNxxP or LxLxL as the identifying hexapeptide motif. In rice (Oryza sativa), we have identified a total of 266 DLN repressor
Purnima Singh, Iny Mathew, Ankit Verma, Akhilesh Tyagi, Pinky Agarwal   +4 more
openaire   +2 more sources

KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions

Current Genomics, 2013
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest individual family of transcriptional repressors encoded by the genomes of higher organisms.
A. Lupo, Elena Cesaro, Giorgia Montano, D. Zurlo, P. Izzo, P. Costanzo   +5 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

PCGF5 is required for neural differentiation of embryonic stem cells

Nature Communications, 2018
Polycomb-group proteins are key regulators of transcriptional programs that maintain cell identity. Here the authors provide evidence that PCGF5, a subunit of Polycomb Repressor Complex 1, is important for the differentiation of mouse embryonic stem ...
Mingze Yao, Xueke Zhou, Jiajian Zhou, Shixin Gong, Gongcheng Hu, Jiao Li, Kaimeng Huang, Ping Lai, Guang Shi, Andrew P. Hutchins, Hao Sun, Huating Wang, Hongjie Yao   +12 more
doaj   +1 more source

Classes of fast and specific search mechanisms for proteins on DNA

, 2011
Problems of search and recognition appear over different scales in biological systems. In this review we focus on the challenges posed by interactions between proteins, in particular transcription factors, and DNA and possible mechanisms which allow for ...
Abramowitz M, Adam G, Alon U, Benichou O, Braun E, Bresloff J L, Bustamante C, de Haan L, Eliazar I, Elowitz M B, Fersht A, Gasch A P, Grosberg A, Hill A V, Hughes B D, Jeltsch A, M Sheinman, Mirny L, Montroll E W, O Bénichou, Oshanin G, Phillips R, R Voituriez, Redner S, Richey B, Sheinman M, Sheinman M Kafri Y, Terry B J, von Hippel P H, von Hippel P H, von Smoluchowski M, Y Kafri, Zhang M O   +32 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Transcriptional silencing in Saccharomyces cerevisiae: known unknowns

Epigenetics & Chromatin
Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form of gene repression. It involves DNA silencers and repressor proteins that bind nucleosomes.
Namrita Dhillon, Rohinton T. Kamakaka
doaj   +1 more source