Results 211 to 220 of about 264,833 (258)

Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin‐Independent Regulation of Fpn mRNA

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT The iron regulatory hormone hepcidin contributes to the pathogenesis of anemia of inflammation (AI) by inhibiting the iron exporter ferroportin in target cells, causing hypoferremia. Under acute inflammation, hepcidin induction requires hemojuvelin (Hjv), a bone morphogenetic protein co‐receptor, while Fpn mRNA is also suppressed in a hepcidin‐
Siqi Liu   +3 more
wiley   +1 more source

The retinoblastoma protein as a transcriptional repressor

Trends in Cell Biology, 1993
The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene products. Its loss during the genesis of many human tumours, its inactivation by several DNA tumour virus oncoproteins, and its ability to inhibit cell growth when introduced into dividing cells all suggest that pRB negatively regulates some aspect of normal cell growth.
Helin, K, Ed, H
openaire   +3 more sources

Bacteriophage Coat Protein as Repressor

Nature, 1968
It seems that viral coat protein acts as a repressor of protein synthesis at the level of transcription rather than translation.
Robert E. Webster   +2 more
openaire   +3 more sources

Modelling repressor proteins docking to DNA

Proteins: Structure, Function, and Genetics, 1998
The docking of repressor proteins to DNA starting from the unbound protein and model-built DNA coordinates is modeled computationally. The approach was evaluated on eight repressor/DNA complexes that employed different modes for protein/ DNA recognition.
Michael J.E. Sternberg   +5 more
openaire   +3 more sources

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