Results 281 to 290 of about 6,797,208 (350)

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

Advanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, Shi‐Mei Zhuang   +10 more
wiley   +1 more source

Mammalian synthetic gene circuits for biopharmaceutical development & manufacture. [PDF]

NPJ Syst Biol Appl
Lim SLY, Gialamoidou S, Kaur R, Jimenez Del Val I.   +3 more
europepmc   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Genome Sequences of Cluster A Mycobacteriophages Dorothea and LappelDuVide, Isolated on <i>Mycobacterium smegmatis</i> mc ² 155. [PDF]

MicroPubl Biol
Pasterczyk N, Wilson C, Broker Z, Chobor A, Daughtry D, Dibor O, John A, Kandru S, Kodirova M, Mulligan C, Owate C, Pistone O, Smith S, Teitelman S, Victor S, Oganovich P, Hult M, Hooper R, Novak E, Mariaca S, Graham L, Mensah S, Kenna M, Ware V.   +23 more
europepmc   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Enhanced Epigenetic Modulation via mRNA-Encapsulated Lipid Nanoparticles Enables Targeted Anti-inflammatory Control. [PDF]

ACS Synth Biol
Mokhtari T, Taheri MN, Akhlaghi S, Aryannejad A, Xiang Y, Mahajan V, Keshavarz K, Kiani A, Yang S, LoPresti S, LeGraw R, Whitehead KA, Kiani S.   +12 more
europepmc   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Regulation of proteolysis of the sigma factor RpoS by the Gac-Rsm signal transduction system in <i>Azotobacter vinelandii</i>. [PDF]

Microbiology (Reading)
Rojo-Rodríguez JB, Moreno S, Espin G.
europepmc   +1 more source

Auxin-mediated seed germination and crosstalk with other phytohormones. [PDF]

Front Plant Sci
Ament A, Kuchařová A, Vladejić J, Bělíček J, Brunoni F, Novák O.   +5 more
europepmc   +1 more source

Mechanisms of Arsenic Interaction in <i>Bacillus subtilis</i> and Related Species with Biotechnological Potential. [PDF]

Int J Mol Sci
Valenzuela-García LI, Alarcón-Herrera MT, Cisneros-Lozano E, Pedraza-Reyes M, Ayala-García VM.   +4 more
europepmc   +1 more source