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Syndromes of thyroid hormone resistance

American Journal of Physiology-Endocrinology and Metabolism, 1982
Resistance to the action of thyroid hormone can involve both peripheral tissues and the pituitary (global resistance), the pituitary only or peripheral tissues alone. Global resistance is of variable severity and has been observed in more than 60 individuals, the majority occurring in 17 families.
S. Refetoff
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The Thyroid Hormone Receptors: Molecular Basis of Thyroid Hormone Resistance

Hormone Research, 1992
Major progress has been achieved in the mechanism of action of thyroid hormones thanks to the identification of the T3 receptor as the product of the proto-oncogene c-erbA. Recognition of subsets of receptors with and without T3-binding properties and of the interaction of different receptors with each other leads to new insights in cell regulation and
De Nayer, Philippe
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Resistance to Thyroid Hormone

Hormone Research, 2009
Resistance to thyroid hormone (RTH) is usually dominantly inherited and is characterized by elevated free thyroid hormones in the serum and failure to suppress pituitary thyroid stimulating hormone (TSH) secretion with variable refractoriness to hormone action in peripheral tissues.
Christian G. Bien, Christian E. Elger, Ali R. Afzal, Sirajedin Natah, Ritva Häyrinen-Immonen, Yrjö Konttinen, George S. Zubenko, John-John B. Schnog, Victor E. A. Gerdes, Mark A. Marinella, Alfried Kohlschütter, Tam Nguyen, Anushree C. Shirali, Daniel R. Goldstein, Millie Samaniego, Bruce Kaplan, Ann-Sofie Hansson, Julie Raggio, William J. Welch, Bin Tean Teh, Ximing J. Yang, Bin Sing Teh, Richard J. Kahnoski, Nicholas J. Vogelzang, Sudha K. Iyengar, Barry I. Freedman, Oded Sperling, Naranjan S. Dhalla, Harjot K. Saini, Seda Sancak, Ralf Paschke, Richard J. Sugrue, Keiji Kuba, Yumiko Imai, Josef Penninger, Jan Kassubek, Alexander Unrath, Margaret R. Wallace, Daniel F. Pauly, Alfredo Chetta, Dario Olivieri, Klaus Ruether, Wolfgang Berger, Dietmar Lohmann, Gabriele E. Lang, Peter Huppke, Johannes Häberle, Jean-Marc Nuoffer, Andrew C. Steer, Jonathan R. Carapetis, Iain B. McInnes, Javier Rangel-Moreno, Troy D. Randall, Werner J. Heppt, Annette Cryer, Annemieke M. Bams-Mengerink, Pedro Brites, Bwee Tien Poll-The, Ronald J. A. Wanders, Harriet S. Tenenhouse, Siobhan D. Ma, Patrick T. S. Ma, Alexander K. C. Leung, Joerg Zehelein, Markus Khalil, Michael Koenen, Christos C. Zouboulis, Alexander K. C. Leung, Kevin Kaplan, Robert J. Meislin, Alexander K. C. Leung, H. Dele Davies, Dieter Metze, Peter L. M. Jansen, Alexander K. C. Leung, Reginald S. Sauve, William Lane M. Robson, Cristina Gervasini, Angela Bentivegna, Lidia Larizza   +79 more
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Thyroid hormone resistance

Postgraduate Medical Journal, 2008
Abstract Thyroid hormone resistance (THR) is a rare syndrome of reduced end organ sensitivity. Patients with THR have elevated serum free thyroxine (FT4), free triiodothyronine (FT3), but normal or slightly elevated serum thyrotropin values.
N K, Agrawal, R, Goyal, A, Rastogi, D, Naik, S K, Singh   +4 more
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Thyroid Hormone Resistance

Annual Review of Medicine, 1992
Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid ...
R E, Weiss, S, Refetoff
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