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Syndromes of Resistance to Thyroid Hormone
2022Abstract Disorders of cellular uptake, metabolism, or action of thyroid hormones comprise syndromes of resistance to thyroid hormone. Reduced entry of thyroid hormones into the central nervous system via a membrane transporter mediates severe mental and psychomotor retardation associated with peripheral hyperthyroidism.
Carla Moran +2 more
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Molecular and Cellular Endocrinology, 2017
Thyroid hormone (TH) is crucial for normal development and metabolism of virtually all tissues. TH signaling is predominantly mediated through binding of the bioactive hormone 3,3',5-triiodothyronine (T3) to the nuclear T3-receptors (TRs). The intracellular TH levels are importantly regulated by transporter proteins that facilitate the transport of TH ...
Stefan Groeneweg +2 more
exaly +3 more sources
Thyroid hormone (TH) is crucial for normal development and metabolism of virtually all tissues. TH signaling is predominantly mediated through binding of the bioactive hormone 3,3',5-triiodothyronine (T3) to the nuclear T3-receptors (TRs). The intracellular TH levels are importantly regulated by transporter proteins that facilitate the transport of TH ...
Stefan Groeneweg +2 more
exaly +3 more sources
Journal of Clinical Endocrinology and Metabolism, 1980
We have previously described an inherited syndrome best explained as peripheral resistance to the action of thyroid hormone. So far, studies were carried out principally in two affected siblings, the third being too young. These studies concentrated on the demonstration of authenticity of the circulating thyroid hormones, their metabolism, the lack of ...
Samuel Refetoff +2 more
exaly +3 more sources
We have previously described an inherited syndrome best explained as peripheral resistance to the action of thyroid hormone. So far, studies were carried out principally in two affected siblings, the third being too young. These studies concentrated on the demonstration of authenticity of the circulating thyroid hormones, their metabolism, the lack of ...
Samuel Refetoff +2 more
exaly +3 more sources
Biochimie, 1999
Lipoproteins, especially HDL, are carriers of a small fraction of the thyroid hormones in plasma and participate in the intracellular transport of T4. In previous work we showed that a brief period of hypothyroidism alters the hormone distribution among the lipoproteins, causing a decrease in VLDL and LDL binding despite a relative increase in VLDL and
BENVENGA, Salvatore, ROBBINS J.
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Lipoproteins, especially HDL, are carriers of a small fraction of the thyroid hormones in plasma and participate in the intracellular transport of T4. In previous work we showed that a brief period of hypothyroidism alters the hormone distribution among the lipoproteins, causing a decrease in VLDL and LDL binding despite a relative increase in VLDL and
BENVENGA, Salvatore, ROBBINS J.
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[Syndromes of thyroid hormone resistance].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 1997The authors have presented the contemporary knowledge concerning the syndromes of thyroid hormone resistance. There are three forms of this syndrome: Generalized Resistance of Thyroid Hormone, Pituitary Resistance to Thyroid Hormone and Peripheral Tissue Resistance to Thyroid Hormone. The illness appears in both family and sporadic forms. Etiology with
J M, Wis, M, Grzywa
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[Syndrome of resistance to thyroid hormones].
Presse medicale (Paris, France : 1983), 1994Although rare, thyroid hormone resistance syndrome should be suspected on a biological profile combining high thyroid hormone and non-suppressed TSH plasma levels. Resistance to thyroid hormone can be classified into 3 forms: generalized, pituitary and peripheral, all three showing tissue resistance heterogeneity from one person to another, and from ...
C, Mechain +4 more
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The Syndrome of Generalized Resistance to Thyroid Hormone (Grth)
Endocrine Research, 1989(1989). The Syndrome of Generalized Resistance to Thyroid Hormone (Grth) Endocrine Research: Vol. 15, No. 4, pp. 717-743.
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[Thyroid hormone resistance syndrome].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2006Resistance to thyroid hormones (RTH) is an inherited syndrome characterised by reduced target tissue responsiveness to these hormones. In the recent years, it has become clear that RTH is probably much more common than is generally recognised, and is often misdiagnosed and inaccurately treated.
Robert, Krysiak +2 more
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The Variable Clinical Phenotype in Thyroid Hormone Resistance Syndrome
Thyroid, 1994Thyroid hormone resistance syndrome (RTH) is a rare disorder characterized by elevated levels of circulating free thyroid hormones, inappropriate TSH secretion, and reduced peripheral tissue responses to iodothyronine action. On the basis of clinical features, at least two different forms of RTH have been described: generalized resistance (GRTH) in ...
P, Beck-Peccoz, V K, Chatterjee
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The Syndrome of Resistance to Thyroid Hormone, Misdiagnosed and Treated as Thyrotoxicosis
Endocrine Practice, 1998To report two cases of resistance to thyroid hormone and to promote increased awareness of this syndrome, which is frequently misdiagnosed and incorrectly treated.We describe a young woman and her father, both of whom were diagnosed at a younger age as having thyrotoxicosis and were treated with thyroidectomy and radioactive iodine. Both patients later
I A, Mohammed +5 more
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