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Resolution of Inflammation: What Controls its Onset? [PDF]
Frontiers in Immunology, 2016 An effective resolution program may be able to prevent the progression from non-resolving acute inflammation to persistent chronic inflammation. It has now become evident that coordinated resolution programs initiate shortly after inflammatory responses ...
Michelle Amantéa Sugimoto +7 more
doaj +13 more sources
Resolution of inflammation in obesity-induced liver disease [PDF]
Frontiers in Immunology, 2012 Low-grade inflammation in adipose tissue is recognized as a critical event in the development of obesity-related co-morbidities. This chronic inflammation is powerfully augmented through the infiltration of macrophages, which together with adipocytes ...
Bibiana eRius +10 more
doaj +4 more sources
Resolution of inflammation: an integrated view [PDF]
EMBO Molecular Medicine, 2013 Resolution of inflammation is a coordinated and active process aimed at restoration of tissue integrity and function. This review integrates the key molecular and cellular mechanisms of resolution.
Almudena Ortega‐Gómez +2 more
doaj +7 more sources
Resolution of Inflammation in Retinal Disorders: Briefly the State. [PDF]
Int J Mol Sci, 2022 The most frequent retinal diseases, such as diabetic retinopathy, age-related macular degeneration and posterior uveitis, are underlined by oxidative stress or aging-induced retinal inflammation, which contributes to vision impairing or loss.
Trotta MC +10 more
europepmc +4 more sources
Targeting Angiogenesis via Resolution of Inflammation. [PDF]
Cold Spring Harb Perspect Med, 2023 Angiogenesis, the growth of new blood vessels, plays a critical role in tissue repair and regeneration, as well as in cancer. A paradigm shift is emerging in our understanding of the resolution of inflammation as an active biochemical process with the ...
Kelly AG, Panigrahy D.
europepmc +4 more sources
The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation. [PDF]
Immunol Rev, 2023 The phagocytosis of dying cells by macrophages, termed efferocytosis, is a tightly regulated process that involves the sensing, binding, engulfment, and digestion of apoptotic cells. Efferocytosis not only prevents tissue necrosis and inflammation caused
Schilperoort M +5 more
europepmc +2 more sources
Targeting Neutrophils for Promoting the Resolution of Inflammation. [PDF]
Front Immunol, 2022 Acute inflammation is a localized and self-limited innate host-defense mechanism against invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in humans, play pivotal roles in host defense by eradicating invading pathogens and
Filep JG.
europepmc +2 more sources
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications. [PDF]
Biomaterials, 2021 Impaired bone healing occurs in 5-10% of cases following injury, leading to a significant economic and clinical impact. While an inflammatory response upon injury is necessary to facilitate healing, its resolution is critical for bone tissue repair as ...
Newman H, Shih YV, Varghese S.
europepmc +2 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims Proper resolution of inflammation is essential to maintaining homeostasis, which is important as a dysregulated inflammatory response has adverse consequences, even being regarded as a hallmark of cancer. However, our picture of dynamic
Yen-ting Ho +11 more
semanticscholar +2 more sources
Resolution of inflammation: a new therapeutic frontier [PDF]
Nature reviews. Drug discovery, 2016 Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success.
J. Fullerton, D. Gilroy
semanticscholar +3 more sources