Results 221 to 230 of about 423,838 (252)
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1988
For centuries, the inflammatory response has been regarded as an important consequence of injury and one that normally leads to repair and restoration of function. From the battlefield observations of John Hunter in 1794 to the elegant vascular studies of Cohnheim (1889) and the descriptions of cell migration by Metchnikoff (1891) a century later, the ...
Christopher Haslett, Peter M. Henson
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For centuries, the inflammatory response has been regarded as an important consequence of injury and one that normally leads to repair and restoration of function. From the battlefield observations of John Hunter in 1794 to the elegant vascular studies of Cohnheim (1889) and the descriptions of cell migration by Metchnikoff (1891) a century later, the ...
Christopher Haslett, Peter M. Henson
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Initiation and Resolution of Mucosal Inflammation
Immunologic Research, 2004Antigens entering the body through the mucosal surface are screened by a highly developed immune system comprised not only of traditional lymphoid cells but also epithelial cells, fibroblasts, and antigen-presenting cells (APCs). For example, in the intestinal tract, gut-associated lymphoid tissue (GALT) is tolerant to the approx 400 separate commensal
Melanie A, Sherman, Daniel, Kalman
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Resolution of Lung Inflammation by CD44
Science, 2002Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation.
Priit, Teder +7 more
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COX-2 in Inflammation and Resolution
Molecular Interventions, 2006Aspirin and the other NSAIDs have popularized the notion of inhibiting prostaglandins as a common anti-inflammatory strategy based on the erroneous premise that all eicosanoids are, within the context of inflammation, generally detrimental. However, our fascination with aspirin and the emergence of COX-2 has shown a more affable side to lipid mediators
Ravindra, Rajakariar +2 more
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2006
Inflammation requires clearance of the inciting pathogen, then orchestrated removal of the burden of leukocytes and other cells influxed into the inflamed site along with dissipation of the pro (or anti) inflammatory mediator cascades. We now recognize that this resolution process is strictly controlled by a number of mediators and adhesion molecules ...
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Inflammation requires clearance of the inciting pathogen, then orchestrated removal of the burden of leukocytes and other cells influxed into the inflamed site along with dissipation of the pro (or anti) inflammatory mediator cascades. We now recognize that this resolution process is strictly controlled by a number of mediators and adhesion molecules ...
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Triggering and resolution of inflammation in NASH
Nature Reviews Gastroenterology & Hepatology, 2018Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular injury and different degrees of fibrosis. A central issue in this field relates to the identification of those factors that trigger inflammation, thus fuelling the ...
Schuster, Susanne +3 more
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Cellular resolution of inflammation—catabasis
Wound Repair and Regeneration, 2012AbstractControlled inflammation has become a central focus in chronic disease therapeutics. Exaggerated inflammation is a common factor that contributes to matrix destruction, cellular senescence, and nonhealing in a variety of disease processes. Efforts at controlling inflammation have traditionally concentrated on systemic antagonists to inflammation
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Lipoxins, Resolvins, and the Resolution of Inflammation
2016Resolution of acute inflammation is an active process, where endogenous specialized pro-resolving mediators (SPM), derived from polyunsaturated fatty acids via lipoxygenase (LO)-driven biochemical pathways, have pivotal roles in “turning off” pro-inflammatory signals, prompting timely resolution.
RECCHIUTI, ANTONIO +3 more
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The Resolution of Inflammation
Inflammopharmacology, 2008Adriano G. Rossi, Deborah A. Sawatsky
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Resolution of chronic inflammation and cancer
Periodontology 2000AbstractChronic inflammation poses challenges to effective cancer treatment. Although anti‐inflammatory therapies have shown short‐term benefits, their long‐term implications may be unfavorable because they fail to initiate the necessary inflammatory responses. Recent research underscores the promise of specialized pro‐resolving mediators, which play a
Kantarci, Alpdogan +4 more
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