Results 61 to 70 of about 2,474,096 (395)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Generalized Response Surface Methodology: A New Metaheuristic [PDF]
SSRN Electronic Journal, 2006 Generalized Response Surface Methodology (GRSM) is a novel general-purpose metaheuristic based on Box and Wilson.s Response Surface Methodology (RSM).Both GRSM and RSM estimate local gradients to search for the optimal solution.These gradients use local first-order polynomials.GRSM, however, uses these gradients to estimate a better search direction ...
openaire +4 more sources
On some aspects of second order response surface methodology : a thesis presented in partial fulfilment of the requirements for the degree of M. Sc. in Mathematics at Massey University [PDF]
, 1972 A unified development of the theoretical basis of response surface methodology, particularly as it applies to second order response surfaces, is presented.
Thomas, Vernon John
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Application of Response Surface Methodology in Food Process Modeling and Optimization
Response Surface Methodology in Engineering Science [Working Title], 2021 Modeling and optimization is an important task in food manufacturing. It enables one to understand and describe processes which in turn help establish quantified relationship between input and output variables.
Solomon Worku Kidane
semanticscholar +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Optimal Machining Parameters for Achieving the Desired Surface Roughness in Turning of Steel
The Journal of Engineering Research, 2012 Due to the widespread use of highly automated machine tools in the metal cutting industry, manufacturing requires highly reliable models and methods for the prediction of output performance in the machining process.
LB Abhang, M Hameedullah
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Saudi Pharmaceutical JournalAn orally administered bilayer tablet with Tamsulosin (TAM) as the sustained release (SR) and Finasteride (FIN) as immediate release (IR) was manufactured.
Muneeba Akhtar +11 more
doaj +1 more source
Antioxidants, 2015 The macadamia is native to Australia and is now grown commercially around the world. Macadamia skin, known as waste, has been generated abundantly, but this ample source has had limited uses as a byproduct.
Adriana Dailey, Quan V. Vuong
doaj +1 more source