Results 41 to 50 of about 1,662,191 (275)
Restriction Factors Against Human CMV
Future Virology, 2014 Cellular proteins called 'restriction factors' (RFs) form an important component of the innate immune response to viral replication. However, viruses have learned how to antagonize RFs through mechanisms that are specific for each virus. Here, we summarize the general hallmarks of RFs before going on to discuss the specific strategies recruited by some
LANDOLFO, Santo Giuseppe +2 more
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Host Restriction Factors Blocking Retroviral Replication [PDF]
Annual Review of Genetics, 2008 Retroviruses are highly successful intracellular parasites, and as such they are found in nearly all branches of life. Some are relatively benign, but many are highly pathogenic and can cause either acute or chronic diseases. Therefore, there is tremendous selective pressure on the host to prevent retroviral replication, and for this reason cells have
Daniel, Wolf, Stephen P, Goff
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Interferon, restriction factors and SUMO pathways
Cytokine & Growth Factor Reviews, 2020 SUMOylation is a reversible post-translational modification that regulates several cellular processes including protein stability, subcellular localization, protein-protein interactions and plays a key role in the interferon (IFN) pathway and antiviral defense.
El-Asmi, Faten +3 more
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R Factor-Controlled Restriction and Modification of Deoxyribonucleic Acid: Restriction Mutants [PDF]
Journal of Bacteriology, 1972 Restriction mutants of two different R factor-controlled host specificities (RI and RII) were isolated. All of the restriction mutants examined had a normal modification phenotype. No complementation was observed between the RI and RII host specificities.
R, Yoshimori +2 more
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Vpu and BST2: still not there yet?
Frontiers in Microbiology, 2012 Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV-1 replication and are widely accepted as ‘restriction factors’.
Kei eSato +3 more
doaj +1 more source
Continuous and discrete flows on operator algebras
, 2005 Let $(N,\R,\theta)$ be a centrally ergodic W* dynamical system. When $N$ is not a factor, we show that, for each $t\not=0$, the crossed product induced by the time $t$ automorphism $\theta_t$ is not a factor if and only if there exist a rational number ...
BENJAMÍN A. ITZÁ-ORTIZ +4 more
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Structural basis for the antiviral activity of BST-2/tetherin and its viral antagonism
Frontiers in Microbiology, 2011 The interferon-inducible host restriction factor bone marrow stromal antigen 2 (BST-2/tetherin) blocks the release of HIV-1 and other enveloped viruses.
Juan F. eArias +2 more
doaj +1 more source
Structural Insights into APOBEC3-Mediated Lentiviral Restriction
Viruses, 2020 Mammals have developed clever adaptive and innate immune defense mechanisms to protect against invading bacterial and viral pathogens. Human innate immunity is continuously evolving to expand the repertoire of restriction factors and one such family of ...
Krista A. Delviks-Frankenberry +2 more
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Tbr1 instructs laminar patterning of retinal ganglion cell dendrites. [PDF]
, 2018 Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae ...
Chen, Bin +7 more
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Gene Therapy Strategies to Exploit TRIM Derived Restriction Factors against HIV-1
Viruses, 2014 Restriction factors are a collection of antiviral proteins that form an important aspect of the innate immune system. Their constitutive expression allows immediate response to viral infection, ahead of other innate or adaptive immune responses.
Emma Chan, Greg J. Towers, Waseem Qasim
doaj +1 more source