Results 51 to 60 of about 60,412 (260)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Challenges and Opportunities in Multi‐Method Integrated Geophysical Prospection of Buried Building Remains at the Sanctuary of Olympia

Archaeological Prospection, EarlyView.
ABSTRACT Ancient Olympia was one of the most important sanctuaries and the venue for the Olympic Games in Greek and Roman times. Its remains are located in the Olympia Terrace (Peloponnese, Greece) at the present‐day confluence of the rivers Alpheios and Kladeos at the base of Mount Kronos.
Sarah Bäumler, Dennis Wilken, Peter Fischer, Lena Slabon, Timo Willershäuser, Birgitta Eder, Hans‐Joachim Gehrke, Erofili‐Iris Kolia, Franziska Lang, Oliver Pilz, Andreas Vött   +10 more
wiley   +1 more source

Poseidon's Sanctuary at Samikon—The Discovery of an Ancient Temple Through an Integrated Geophysical and Geoarchaeological Survey Approach for Lagoonal and Swampy Environments

Archaeological Prospection, EarlyView.
ABSTRACT Below the classical fortress of Samikon at the coast of the western Peloponnese, ancient writer Strabo mentioned a sanctuary of Poseidon which served as the centre of the religious association of the Triphylian cities. In this paper, we describe the discovery and investigation of a building structure by means of geophysical and ...
Dennis Wilken, Birgitta Eder, Sarah Bäumler, Elena Appel, Peter Fischer, Tina Georg, Federica Iannone, Lena Slabon, Timo Willershäuser, Erofili‐Iris Kolia, Andreas Vött   +10 more
wiley   +1 more source

Technology Transfer to Underwater Archaeology: The LAHKE Project at the Submerged Neolithic Site of La Marmotta

Archaeological Prospection, EarlyView.
ABSTRACT This document is a report on the field application of non‐invasive geophysical and robotic prospecting methods at the submerged Neolithic site of La Marmotta (Lake Bracciano, Italy), within the LAHKE (LAke Heritage Knowledge and Exploration) project; the study focuses on the practical validation, adaptation and transfer of existing ...
dell' Erba Ramiro, Cupertino Giacomo, Cipollini Angelo, Luciano Blasi, Quattrucci Luca   +4 more
wiley   +1 more source

Atypical Long Barrows in the Cöeby Neolithic Cemetery (Trédion, Morbihan, France)? The Contribution of Electrical Surveys

Archaeological Prospection, EarlyView.
ABSTRACT The Coëby Neolithic cemetery, located in the commune of Trédion (Morbihan, France) and discovered in 1986, has been for several years the subject of a research programme focused on studying the various megalithic structures present. The spatial distribution of these remains highlights an unusual occupation of the territory, organized according
Philippe Gouézin, Vivien Mathé
wiley   +1 more source

A Metastatic Pulmonary Sarcomatoid Carcinoma Patient Harboring KIF5B-RET Fusion Responds to First-Line Pralsetinib Treatment: A Case Report

Cancer Management and Research, 2023
Hao Qin,1,* Yuxiang Wan,2,* Yuchao Dong,1 Qinying Sun1 1Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, People’s Republic of China ...
Qin H, Wan Y, Dong Y, Sun Q
doaj  

Choice of surgery extension in medullary thyroid cancer

Эндокринная хирургия, 2011
Medullary thyroid cancer (MTC) has high level of clinical aggressiveness as well as high recurrence rate par ticularly metastases in regional lymph nodes.
P O Rumyantsev, A A Ilyin, U V Rumyantseva   +2 more
doaj   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Hereditary pheochromocytoma/paraganglioma and associated syndromes: a clinical and genetic study

陆军军医大学学报
Objective To summarize and analyze the clinical phenotypes, hereditary features and treatment and follow-up strategies of different hereditary pheochromocytoma/paragangliomas (PCC/PGL) and related syndromes.
TANG Peng, LAN Weihua, ZHANG Yao
doaj   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source