Results 61 to 70 of about 94,066 (297)

GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling

Biology Open, 2013
Summary A significant fraction of mice deficient in either glial cell-derived neurotrophic factor (GDNF) or its co-receptors (Gfrα1, Ret), undergoes ureteric bud (UB) outgrowth leading to the formation of a rudimentary kidney.
James B. Tee, Yohan Choi, Ankur Dnyanmote, Marvalyn Decambre, Chiharu Ito, Kevin T. Bush, Sanjay K. Nigam   +6 more
doaj   +1 more source

The role of autophagy in the thyroid tumors development, connection with the AKT/m-TOR signaling pathway activation

Клиническая и экспериментальная тиреоидология, 2020
Autophagy is an important intracellular process that supports cell death and survival. Oncogenesis is associated with a change in the AKT/mTOR signaling pathway status.
Liudmila V. Spirina, Sventlana Yu. Chizhevskaya, Irina V. Kondakova, Nataliya V. Tarasenko   +3 more
doaj   +1 more source

Bayesian Optimization–Reinforcement Learning Hybrid Framework for a‐IGZO Thin‐Film Transistor Compact Model Parameter Extraction in 2T0C Dynamic Random Access Memory Applications

Advanced Intelligent Systems, EarlyView.
A training‐free two‐stage BO–RL framework extracts compact model parameters for a‐IGZO TFTs, reaching BO‐level fitting quality at a constant per‐simulation optimization cost. Bayesian optimization performs exploration and provides an optimized starting point.
Seunghyun Son, Taejun Ha, Taeyoung Nam, Yoonyoung Chung, Sunmean Kim   +4 more
wiley   +1 more source

Differential Diagnosis of Mucopolysaccharidoses Types I, II, III, IVA, and VI Through Analysis of Leukocytic Inclusions

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by the accumulation of glycosaminoglycans (GAGs), which can lead to cytoplasmic alterations in leukocytes. The objective of this study was to characterize leukocyte inclusions in patients with different types of MPS and assess their diagnostic relevance.
Márcio A. W. Melo, Marcelo S. Kertenetzky, Cristina M. Silveira, Maíra M. Ribeiro, Paula F. Medeiros, Gabriela S. Arcanjo   +5 more
wiley   +1 more source

An integrative pan cancer analysis of RET aberrations and their potential clinical implications

Scientific Reports, 2022
RET (rearranged during transfection), encoding a tyrosine kinase receptor, is a novel therapeutic target for cancers. The aberrations of RET are commonly found in cancers.
Lei Zhou, Juanni Li, Xiaofang Zhang, Zhijie Xu, Yuanliang Yan, Kuan Hu   +5 more
doaj   +1 more source

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]

, 2007
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu, Edgar R Kramer, Zhuang, Xiaoxi, Zhuang, X. X., Klein, R., Klaus Beyer, Geert M J Ramakers, Smidt, M. P., Smidt, Marten P., Kramer, E., Ramakers, Geert M. J., Klein, Rüdiger, Beyer, K., Seitz, S., Marten P Smidt, Ramakers, G., Xiaoxi Zhuang, Beyer, Klaus, Zhuang, X., Liviu Aron, Sabine Seitz, Rüdiger Klein, Smidt, M., Seitz, Sabine, Kramer, Edgar R., Aron, L., Ramakers, G. M. J., Kramer, E. R., Kramer Edgar R, Ramakers, Geert M. J, Smidt Marten P, Ramakers Geert M. J, Seitz Sabine, Aron Liviu, Zhuang Xiaoxi, Beyer Klaus, Klein Rüdiger   +36 more
core   +2 more sources

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

A Metastatic Pulmonary Sarcomatoid Carcinoma Patient Harboring KIF5B-RET Fusion Responds to First-Line Pralsetinib Treatment: A Case Report

Cancer Management and Research, 2023
Hao Qin,1,* Yuxiang Wan,2,* Yuchao Dong,1 Qinying Sun1 1Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, People’s Republic of China ...
Qin H, Wan Y, Dong Y, Sun Q
doaj  

Choice of surgery extension in medullary thyroid cancer

Эндокринная хирургия, 2011
Medullary thyroid cancer (MTC) has high level of clinical aggressiveness as well as high recurrence rate par ticularly metastases in regional lymph nodes.
P O Rumyantsev, A A Ilyin, U V Rumyantseva   +2 more
doaj   +1 more source

Hereditary pheochromocytoma/paraganglioma and associated syndromes: a clinical and genetic study

陆军军医大学学报
Objective To summarize and analyze the clinical phenotypes, hereditary features and treatment and follow-up strategies of different hereditary pheochromocytoma/paragangliomas (PCC/PGL) and related syndromes.
TANG Peng, LAN Weihua, ZHANG Yao
doaj   +1 more source