Results 81 to 90 of about 94,066 (297)

Familial Clinical Heterogeneity of Medullary Thyroid Cancer with Germline RET S891A Protooncogene Mutation: 7-year Follow-up with Successful Sorafenib Treatment

open access: yesJCRPE
Hereditary forms of medullary thyroid carcinoma (MTC) are rare. Different phenotypes with the same mutation may be due to differences in the timing of rearranged during transfection (RET) activation steps, additional mutations in other regions of the ...
Sirmen Kızılcan Çetin   +9 more
doaj   +1 more source

Ret-Dependent and Ret-Independent Mechanisms of Gfl-Induced Sensitization

open access: yesMolecular Pain, 2011
Background: The GDNF family ligands (GFLs) are regulators of neurogenic inflammation and pain. We have previously shown that GFLs increase the release of the sensory neuron neuropeptide, calcitonin gene-related peptide (CGRP) from isolated mouse DRG. Results: Inhibitors of the mitogen-activated protein kinase (MAPK) pathway abolished the enhancement of
Meadows Rena M   +4 more
openaire   +3 more sources

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

A Bibliometric Analysis of Medullary Thyroid Carcinoma From 2000 to 2022

open access: yesXiehe Yixue Zazhi
ObjectiveTo review the state of research on medullary thyroid carcinoma (MTC) over the past two decades, so as to offer a quick reference for understanding the current state and future trends in this field.MethodsA computer was employed to search the Web
TAN Meijuan, YANG Shijie, XU Xiequn
doaj   +1 more source

RET-MEN2 tumor growth and survival depends on cytonemes.

open access: yes, 2019
(A-B’) Unfixed wing discs expressing CD8:GFP (green) driven by ptc-Gal4. Scale bar: 100μm. (A) Control. (A’) Cytonemes in wild type cells (green, arrows). Scale bar: 50μm. (B) RET tumor, genotype: ptc-Gal4,CD8:GFP;UAS-RETMEN2/UAS-CD8:GFP.
Ryo Hatori (7444715)   +3 more
core   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

open access: yesBiotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]

open access: yes, 2006
MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core   +1 more source

Renewable Energy Target review [PDF]

open access: yes, 2014
SUMMARY This is the Climate Change Authority\u27s second review of the Renewable Energy Target (RET). The RET targets reductions in greenhouse gas emissions from the electricity sector and thereby contributes significantly to reducing Australia\u27s ...
Climate Change Authority
core  

Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3 [PDF]

open access: yes, 2009
Background: The rearranged during transfection (RET) gene encodes a single-pass receptor whose proper expression and function are essential for the development of enteric nervous system.
Tam, PKH   +6 more
core   +1 more source

Pectinase‐Based Bioprocesses for Circular Bioeconomy and Sustainable Industrial Development

open access: yesBiotechnology and Bioengineering, EarlyView.
This picture demonstrates a unified strategy for sustainable pectinase production, focusing on microbial bioproduction, innovative strategies in enzyme engineering (Protein engineering, rational enzyme design, directed evolution and heterologous expression) and various applications in industry, including food, textiles, pulp and paper, agriculture and ...
Nisha Sharma   +6 more
wiley   +1 more source

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