Results 61 to 70 of about 501,662 (286)

Mutational Analysis in Pediatric Thyroid Cancer and Correlations with Age, Ethnicity, and Clinical Presentation. [PDF]

, 2016
BackgroundWell-differentiated thyroid cancer (WDTC) incidence in pediatrics is rising, most being papillary thyroid carcinoma (PTC). The objective of the study was to assess the prevalence of different mutations in pediatric WDTC and correlate the ...
Cheng, Shih-Min, Hantash, Feras M, Jiang, Wen, McPhaul, Michael J, Newbury, Robert O, Newfield, Ron S, Nikita, Maria Eleni, Phillips, Susan A, Reitz, Richard E, Waldman, Frederic M   +9 more
core   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Choice of surgery extension in medullary thyroid cancer

Эндокринная хирургия, 2011
Medullary thyroid cancer (MTC) has high level of clinical aggressiveness as well as high recurrence rate par ticularly metastases in regional lymph nodes.
P O Rumyantsev, A A Ilyin, U V Rumyantseva   +2 more
doaj   +1 more source

Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET/PTC [PDF]

, 2008
Background RET/PTC (rearranged in transformation/papillary thyroid carcinomas) gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma.
Young-Rae Kim, Hee Sun Byun, Minho Won, Kyeong Ah Park, Jin Man Kim, Byung Lyul Choi, Hyunji Lee, Jang Hee Hong, Jongsun Park, Jeong Ho Seok, Dong Wook Kim, Minho Shong, Seung-Kiel Park, Gang Min Hur, G Tallini, R Ciampi, YE Nikiforov, V Saenko, ZW Baloch, M Santoro, SM Jhiang, M Santoro, DJ Powell Jr, M Santoro, Y Kodama, JH Hwang, JH Exton, WC Colley, PM Steed, SM Hammond, JM Han, M Liscovitch, J Moss, C D'Souza-Schorey, DS Min, L Lucas, JY Sung, G Sa, Y Banno, M Saito, T Joseph, BH Ahn, M Zhong, SD Lee, WT Ho, GH Jossart, G Viglietto, L Wang, JF Bromberg   +48 more
core   +1 more source

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, EarlyView.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source

Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes. [PDF]

, 2010
OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medullary thyroid carcinoma (MTC) associated (MEN 2A and 2B) or not familial MTC (FMTC) with other endocrine neoplasia due to germline RET gene mutations.
Bondi F, Boscaro M, Bottici V, Brandi ML, Cappai A, Cappelli C, Castagna MG, Castellano M, Ceccherini I, Colao A, Cosci B, Cremonini N, degli Uberti E, Elisei R, Faggiano A, Falchetti A, Ferolla P, Francia G, Fugazzola L, Giorgino F, ItaMEN network, Loli P, Mariotti S, Mian C, Opocher G, Orlandi F, Pacini F, Persani L, Pinchera A, Pinna G, Puxeddu E, Romei C, Seregni E, Taccaliti A, Verga U, Zatelli MC   +35 more
core   +1 more source

Threshold‐Voltage Modulation and N2O Plasma Passivation for Enhanced Retention and Memory Window in Capacitorless 2T0C DRAM Oxide Thin‐Film Transistors

Advanced Science, EarlyView.
Al:ITZO‐based capacitorless 2T0C DRAMs are realized by combining N2O plasma‐induced defect modulation with read‐transistor W/L optimization to suppress leakage and stabilize data storage. This device‐level engineering enables zero‐bias hold operation, retention times exceeding 1000 s, and a 13‐fold expansion of the memory window, demonstrating a ...
Chahwan Yang, Mirinae Lee, Junghoon Han, Sooji Nam   +3 more
wiley   +1 more source

Detailed Chemical Abundances in the r-Process-Rich Ultra-Faint Dwarf Galaxy Reticulum 2

, 2016
The ultra-faint dwarf galaxy Reticulum 2 (Ret 2) was recently discovered in images obtained by the Dark Energy Survey. We have observed the four brightest red giants in Ret 2 at high spectral resolution using the Michigan/Magellan Fiber System.
Bailey III, John I., Bell, Eric F., Crane, Jeffrey D., Loebman, Sarah, Mateo, Mario, Nidever, David L., Olszewski, Edward W., Roederer, Ian U., Shectman, Stephen A., Song, Yingyi, Thompson, Ian B., Valluri, Monica, Walker, Matthew G.   +12 more
core   +1 more source