Characterization and vectorization of siRNA targeting RET/PTC1 in human papillary thyroid carcinoma cells [PDF]
, 2011 RET/PTC1 fusion oncogene is the most common genetic alteration identified to date in thyroid papillary carcinomas (PTC) and represents a good target for small interfering RNA (siRNA).
Massade L.
core +1 more source
Advanced Science, EarlyView.This study pioneers an aggregation‐induced resonance energy transfer mechanism by synergistically integrating aggregation‐induced emission (AIE), resonance energy transfer (RET), and thermally activated delayed fluorescence (TADF) within co‐reactant conjugated polymers to develop self‐enhanced ECL emitters, which achieves an ECL efficiency up to 92.6 ...
Chao Wang +6 more
wiley +1 more source
MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity [PDF]
, 1998 We have investigated the genetic circuitry underlying the determination of neuronal identity, using mammalian peripheral autonomic neurons as a model system.
Anderson, David J. +2 more
core
Variational Theory of Balance Systems [PDF]
, 2009 In this work we apply the Poincare-Cartan formalism of the Classical Field Theory to study the systems of balance equations (balance systems). We introduce the partial k-jet bundles of the configurational bundle and study their basic properties: partial ...
Preston, Serge
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Non-equilibrium theories of rarefied gases: internal variables and extended thermodynamics [PDF]
, 2020 Limits of classical constitutive laws such as Fourier and Navier-Stokes equations are discovered since decades. However, the proper extensions -- generalizations of these are not unique.
Kovács, Róbert +3 more
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Advanced Science, EarlyView.Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen +14 more
wiley +1 more source
Biomarker testing in non-small cell lung carcinoma – More is better: A case series
Cancer Research, Statistics, and Treatment, 2020 Background: Biomarker-driven lung adenocarcinomas involving alterations in oncogenic drivers such as EGFR, ALK, ROS1, and NTRK have witnessed a dramatic shift in the therapeutic and prognostic landscape owing to the development of molecular targeted ...
Ullas Batra +6 more
doaj +1 more source
Comprehensive analysis of RET common and rare variants in a series of Spanish Hirschsprung patients confirms a synergistic effect of both kinds of events [PDF]
, 2011 Background RET is the major gene associated to Hirschsprung disease (HSCR) with differential contributions of its rare and common, coding and noncoding mutations to the multifactorial nature of this pathology.
Rocio Núñez-Torres +8 more
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Stabilizing Atomically Dispersed Au With Adjacent Pt for Spatially Precise Molecule Recognition
Advanced Science, EarlyView.A strategy to stabilize atomically dispersed Au catalysts by introducing Pt atoms into CeO2 supports is presented. Pt incorporation prevents Au aggregation, enhances Au‐O orbital coupling, and enables precise recognition of multi‐functionalized molecules, improving catalytic performance and the structural stability of Au‐based catalysts in ...
Rui Tang +12 more
wiley +1 more source
An integrative pan cancer analysis of RET aberrations and their potential clinical implications
Scientific Reports, 2022 RET (rearranged during transfection), encoding a tyrosine kinase receptor, is a novel therapeutic target for cancers. The aberrations of RET are commonly found in cancers.
Lei Zhou +5 more
doaj +1 more source