Results 81 to 90 of about 22,655 (235)
Whole Blood Transcriptomic Analysis of Sickle Cell Trait
European Journal of Haematology, EarlyView.ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson +12 more
wiley +1 more source
The FEBS Journal, EarlyView.NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu +9 more
wiley +1 more source
Haemophilia, EarlyView.ABSTRACT Introduction The National Bleeding Disorder Foundation (NBDF) Medical and Scientific Advisory Council (MASAC) was formed in 1954 and issues recommendations and advisories pertinent to the bleeding disorders community. MASAC is comprised of > 25 rotating members from different medical disciplines and lived experience experts.
Glaivy Batsuli +15 more
wiley +1 more source
Unexplained Elevated Vitamin B12: Consider Macro‐B12
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction Elevated vitamin B12 concentration can be caused by supplementation, liver disease, kidney disease, or myeloid malignancies. Persistent, unexplained elevations of vitamin B12 can raise concern among patients and may lead to invasive diagnostic procedures, including bone marrow biopsy.
Evelien G. E. Hurkmans +3 more
wiley +1 more source
Journal of Animal Physiology and Animal Nutrition, EarlyView.ABSTRACT Age‐associated changes in intestinal permeability and function have not been studied in domestic cats, leaving a key factor in the relationship between age and digestive health in cats unexplored. Due to factors not currently understood, mature and senior cats may experience a loss of fat and protein digestibility, along with a loss of body ...
Keely Patterson +6 more
wiley +1 more source
Transfusion Medicine, EarlyView.Abstract Solid organ transplant is associated with high rates of anaemia and transfusion, but there is little comparative data on interventions such as erythropoietin‐stimulating agents (ESAs) and intravenous (IV) iron. We conducted a systematic review examining the association of ESAs and IV iron with outcomes in adults undergoing solid organ ...
Frank Lee +13 more
wiley +1 more source
Transfusion, EarlyView.Abstract Background RhD mismatched transfusions in RhD negative women have the potential to impact future pregnancies through alloimmunization and development of hemolytic disease of the fetus and newborn (HDFN). As use of RhD positive emergency‐release blood products in pediatric trauma has increased, it has become clear that a significant ...
Kirea Lange +7 more
wiley +1 more source
Veterinary Clinical Pathology, EarlyView.SUMMARY In dogs, the WDF and WNR scattergrams from the Sysmex XN‐1000V enable a highly presumptive interpretation of mastocytemia. This is the first description of abnormal circulating mast cells using the Sysmex XN‐1000V, which appears to function similarly to the previous analyzer, the Sysmex XT‐2000iV.
Javier Martínez‐Caro +2 more
wiley +1 more source
Relationship between erythropoietin levels and reticulocyte count in sports
Slovak Journal of Sport ScienceThe aim of the study was to determine if a direct relationship could be established between erythropoietin levels and reticulocyte counts in blood samples collected at the same time.
Martin Pupiš +4 more
doaj