Results 81 to 90 of about 28,723 (221)

A comparative pharmacokinetic and pharmacodynamic study of two novel Cuban PEGylated rHuEPO versus MIRCERA® and ior®EPOCIM [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2018
Context: The recombinant human erythropoietin (rHuEPO) stimulates the erythropoiesis process. Because this glycoprotein has a short half-life, it needs to be administrated two to three times a week.
Gledys Reynaldo, Leyanis Rodríguez, Roberto Menéndez, Joaquín Solazábal, Daniel Amaro, María de los A. Becquer, Yamila Colom, Haydee Gil, Juan C. Polo, Gilberto Castañeda, Braulio Jiménez-Vélez, Jorge Duconge, Eduardo M. Fernández-Sánchez   +12 more
doaj  

In vitro kinetics of reticulocyte subtypes: maturation after red blood cell storage in additive solution-1 (AS-1)

Hematology, Transfusion and Cell Therapy, 2018
Background: Reticulocytes are immature red blood cells containing RNA remnants. Their population kinetics has been documented under various in vivo and in vitro conditions, including after storage of red blood cells in blood banks.
Adriana Urbina, Fernando Palomino
doaj   +1 more source

A transient resistance to blood-stage malaria in interferon-γ-deficient mice through impaired production of host cells preferred by malaria parasites

Frontiers in Microbiology, 2015
IFN-γ plays both pathological and protective roles during blood-stage malaria. One of its pathological roles is its contribution to anemia by suppressing erythropoiesis. Here, to evaluate the effects of IFN-γ-mediated alterations in erythropoiesis on the
Hiroko eOkada, Kazutomo eSuzue, Takashi eImai, Tomoyo eTaniguchi, Chikako eShimokawa, Risa eOnishi, Jun eHirata, Hajime eHISAEDA   +7 more
doaj   +1 more source

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities. [PDF]

Am J Hematol
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Bello-Manga H, Abdullahi SU, Hassab H, Brown B, Nduba V, Githanga J, Akinsete AM, El-Beshlawy A, Hanna D, Segbefia C, Okpala I, Tantawy A, Ogutu B, Tubman VN, Paintsil V, Wali Y, Essa M, Telfer P, Dixon S, Hickman A, Doss JF, Davis MW, Rupon J, Kirkham FJ, Brown RC, HOPE Kids 2 Investigators.   +25 more
europepmc   +2 more sources

Association of enlarged perivascular space burden with silent cerebral infarcts in children with sickle cell disease

British Journal of Haematology, EarlyView.
Enlarged perivascular spaces (ePVS) in the basal ganglia and centrum semiovale are highly prevalent in children with sickle cell disease (SCD). Enlarged PVS in the basal ganglia are associated with the presence of silent cerebral infarcts, another marker of neurological disease, in children with SCD. Summary Children with sickle cell disease (SCD) have
Kristine A. Karkoska, Jahnavi Gollamudi, Brady J. Williamson, Russell P. Sawyer, Daniel Woo, Achala Vagal, Hyacinth I. Hyacinth   +6 more
wiley   +1 more source

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Fetal Reticulocytes in Sickle Cell Anemia

, 2002
fetal reticulocytes with Betke ...
Lawrence, Christine
core  

Plasmodium vivax: restricted tropism and rapid remodelling of CD71 positive reticulocytes.

, 2014
Plasmodium vivax merozoites only invade reticulocytes, a minor though heterogeneous population of red blood cell precursors that can be graded by levels of transferrin receptor (CD71) expression.
Claser, C, Malleret, B, Zhang, R, Tan, KS, Chu, CS, Cho, JS, Li, A, Lim, CT, Koh, EG, Ng, LG, Russell, B, Pukrittayakamee, S, Ng, ML, Ginhoux, F, Snounou, G, Nosten, F, Rénia, L, Suwanarusk, R, Lim, Chwee Teck, Tan, Shyong Wei Kevin, Chu, Cindy, Tan, Kevin, Li, Ang, R�nia, Laurent, Ng, Lai Guan, Koh, Geok Liang Esther, Ginhoux, Florent, Cho, Jee Sun, Ng, Laiguan, Suwanarusk, Rossarin, Ng, Mah Lee, Russell, Bruce, Pukrittayakamee, Sasithon, Koh, Esther Geok Liang, Zhang, Rou, Rénia, Laurent, Chu, Cindy S., Snounou, Georges, Malleret, Benoit, Nosten, Fran�ois Henri, Cho, Jeesun, Malleret, Beno�t, Claser, Carla, Russell, Bruce M., Nosten, François   +44 more
core   +1 more source

Flow cytometry in peripheral blood reticulocytes as a marker of chromosome instability in highgrade glioma patients [PDF]

, 2018
Introduction: The quantification of chromosomal instability is an important parameter to assess genotoxicity and radiosensitivity. Most conventional techniques require cell cultures or laborious microscopic analyses of chromosomes or nuclei.
Camargo Guerrero, Mauricio, Camargo, Mauricio, Hugo Grisales, Rojas, Mauricio, León Darío Ortiz, Lina Marcela Barrera, Mauricio Rojas, Grisales Romero, Hugo de Jesús, Barrera Arenas, Lina Marcela, Ortiz, León Darío, Grisales, Hugo, Mauricio Camargo, Barrera, Lina Marcela, Rojas López, Mauricio, Ortiz Gómez, León Darío   +14 more
core   +1 more source

On the Evolution and Function of Plasmodium vivax Reticulocyte Binding Surface Antigen (pvrbsa)

Frontiers in Genetics, 2018
The RBSA protein is encoded by a gene described in Plasmodium species having tropism for reticulocytes. Since this protein is antigenic in natural infections and can bind to target cells, it has been proposed as a potential candidate for an anti ...
Paola Andrea Camargo-Ayala, Paola Andrea Camargo-Ayala, Diego Garzón-Ospina, Diego Garzón-Ospina, Darwin Andrés Moreno-Pérez, Darwin Andrés Moreno-Pérez, Laura Alejandra Ricaurte-Contreras, Oscar Noya, Manuel A. Patarroyo, Manuel A. Patarroyo   +9 more
doaj   +1 more source