Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells [PDF]
Frontiers in Cellular Neuroscience, 2020 The retina and the olfactory bulb are the gateways to the visual and olfactory systems, respectively, similarly using neural networks to initiate sensory signal processing.
Chase B. Hellmer +4 more
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Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa. [PDF]
PLoS ONE, 2012 Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood.
Miao Chen, Ke Wang, Bin Lin
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Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter [PDF]
EMBO Molecular Medicine, 2014 In this report, we describe the development of a modified adeno‐associated virus (AAV) capsid and promoter for transduction of retinal ON‐bipolar cells.
Therese Cronin +11 more
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Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors [PDF]
Cell Reports, 2019 Summary: Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by
Rong-wei Zhang +3 more
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Empowering Retinal Gene Therapy with a Specific Promoter for Human Rod and Cone ON-Bipolar Cells
Molecular Therapy: Methods & Clinical Development, 2020 Optogenetic gene therapy holds promise to restore high-quality vision in blind patients and recently reached clinical trials. Although the ON-bipolar cells, the first retinal interneurons, make the most attractive targets for optogenetic vision ...
Elmar Carlos Hulliger +2 more
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Cis-regulatory basis of sister cell type divergence in the vertebrate retina [PDF]
eLife, 2019 Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood.
Daniel P Murphy +4 more
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Microglial phagocytosis of bipolar cells triggers inner retinal degeneration in Rs1-KO mice [PDF]
Cell Communication and SignalingBackground X-linked juvenile retinoschisis (XLRS) is a hereditary retinal disorder caused by mutations in the RS1 gene that leads to the formation of cavities in the inner nuclear layer (INL) and progressive vision loss, characterized by a ...
Jin Young Yang +10 more
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IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2023 In retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), the photoreceptors become stressed and start to degenerate in the early stages of the disease.
Shayan Farzad +11 more
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Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina [PDF]
eLifeParallel processing is a fundamental organizing principle in the nervous system and understanding how parallel neural circuits generate distinct outputs from common inputs is a key goal of neuroscience. In the mammalian retina, divergence of cone signals
Sidney P Kuo +8 more
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