ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells. [PDF]
J Gen PhysiolAvilés EC +9 more
europepmc +2 more sources
Light Adaptation of Retinal Rod Bipolar Cells [PDF]
The Journal of Neuroscience, 2023 The sensitivity of retinal cells is altered in background light to optimize the detection of contrast. For scotopic (rod) vision, substantial adaptation occurs in the first two cells, the rods and rod bipolar cells (RBCs), through sensitivity adjustments in rods and postsynaptic modulation of the transduction cascade in RBCs.
Khris G. Griffis +3 more
openaire +3 more sources
Compartment models for the electrical stimulation of retinal bipolar cells. [PDF]
PLoS One, 2018 Bipolar cells of the retina are among the smallest neurons of the nervous system. For this reason, compared to other neurons, their delay in signaling is minimal. Additionally, the small bipolar cell surface combined with the low membrane conductance causes very little attenuation in the signal from synaptic input to the terminal.
Rattay F, Bassereh H, Stiennon I.
europepmc +5 more sources
A systematic comparison of optogenetic approaches to visual restoration
Molecular Therapy: Methods & Clinical Development, 2022 During inherited retinal degenerations (IRDs), vision is lost due to photoreceptor cell death; however, a range of optogenetic tools have been shown to restore light responses in animal models. Restored response characteristics vary between tools and the
Michael J. Gilhooley +5 more
doaj +1 more source
A transgenic mouse line expressing cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors. [PDF]
PLoS ONE, 2011 Approaches for manipulating cell type-specific gene expression during development depend on the identification of novel genetic tools. Here, we report the generation of a transgenic mouse line that utilizes Vsx2 upstream sequences to direct Cre ...
Philip E B Nickerson +5 more
doaj +1 more source
Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina
Cell Reports, 2021 Summary: Retinal bipolar cells are second-order neurons that transmit basic features of the visual scene to postsynaptic partners. However, their contribution to motion detection has not been fully appreciated.
Chase B. Hellmer +5 more
doaj +1 more source
Direction selectivity in retinal bipolar cell axon terminals [PDF]
Neuron, 2021 The ability to encode the direction of image motion is fundamental to our sense of vision. Direction selectivity along the four cardinal directions is thought to originate in direction-selective ganglion cells (DSGCs) because of directionally tuned GABAergic suppression by starburst cells.
Matsumoto, Akihiro +6 more
openaire +4 more sources
Serum TRPM1 autoantibodies from melanoma associated retinopathy patients enter retinal on-bipolar cells and attenuate the electroretinogram in mice. [PDF]
PLoS ONE, 2013 Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome associated with cutaneous malignant melanoma and the presence of autoantibodies that label neurons in the inner retina.
Wei-Hong Xiong +5 more
doaj +1 more source
Optogenetic Prosthetization of Retinal Bipolar Cells
Journal of Evolutionary Biochemistry and Physiology, 2022 Abstract Although the experience of optogenetic retinal prosthetics in animal models dates back to more than 16 years, the first results obtained on humans have only been reported in the last year. Over this period, the main challenges of prosthetics became clear and the approaches to their solution were ...
A. Yu. Rotov, M. L. Firsov
openaire +1 more source
iScience, 2022 Summary: Pluripotent stem cell (PSC)-derived retinal sheet transplanted in vivo can form structured photoreceptor layers, contact with host bipolar cells, and transmit light signals to host retinas.
Suguru Yamasaki +10 more
doaj +1 more source