Results 31 to 40 of about 39,677 (234)

Synaptic Depression and the Kinetics of Exocytosis in Retinal Bipolar Cells [PDF]

The Journal of Neuroscience, 2000
The capacitance technique was used to investigate exocytosis at the ribbon synapse of depolarizing bipolar cells from the goldfish retina. When the Ca2+current was activated strongly, the rapidly releasable pool of vesicles (RRP) was released with a single rate-constant of ∼300–500 sec−1.
Burrone, Juan, Lagnado, Leon
openaire   +2 more sources

Hierarchical retinal computations rely on hybrid chemical-electrical signaling

Cell Reports, 2023
Summary: Bipolar cells (BCs) are integral to the retinal circuits that extract diverse features from the visual environment. They bridge photoreceptors to ganglion cells, the source of retinal output.
Laura Hanson, Prathyusha Ravi-Chander, David Berson, Gautam B. Awatramani   +3 more
doaj   +1 more source

Imaging Exocytosis in Retinal Bipolar Cells with TIRF Microscopy [PDF]

Journal of Visualized Experiments, 2009
Total internal reflectance fluorescence (TIRF) microscopy is a technique that allows the study of events happening at the cell membrane, by selective imaging of fluorescent molecules that are closest to a high refractive index substance such as glass. In this article, we apply this technique to image exocytosis of synaptic vesicles in retinal bipolar ...
Joselevitch, Christina, Zenisek, David
openaire   +2 more sources

Knock-Out of Tenascin-C Ameliorates Ischemia-Induced Rod-Photoreceptor Degeneration and Retinal Dysfunction

Frontiers in Neuroscience, 2021
Retinal ischemia is a common pathomechanism in various eye diseases. Recently, evidence accumulated suggesting that the extracellular matrix (ECM) glycoprotein tenascin-C (Tnc) plays a key role in ischemic degeneration.
Susanne Wiemann, Aisha Yousf, Stephanie C. Joachim, Carolin Peters, Ana M. Mueller-Buehl, Natalie Wagner, Jacqueline Reinhard   +6 more
doaj   +1 more source

General features of the retinal connectome determine the computation of motion anticipation [PDF]

, 2015
Motion anticipation allows the visual system to compensate for the slow speed of phototransduction so that a moving object can be accurately located.
Asari, Baylor, Berry, Bischofberger, Blitz, Bollmann, Bonin, Borst, Branco, Branco, Briggman, Bölinger, Cafaro, Calkins, Calkins, Chen, Demb, Dreosti, Esposti, Freed, Gleeson, Gollisch, Goodale, Gouras, Haider, Hao, Hausselt, Haverkamp, Helmstaedter, Hines, Hitchcock, HUBEL, Isaacson, Jakobs, Jarsky, Johnston, Koch, Koizumi, Kolb, Kolb, Kolb, Koontz, Kuzmiski, Lee, Leonardo, Levick, Liu, London, Lukasiewicz, MacNeil, Magee, Malpeli, Manookin, Marshak, Marshak, Masland, Miller, Münch, Nikolaev, Odermatt, Oesch, Olveczky, Owczarzak, Pouille, Quiroga, RALL, Rieke, Roska, Schachter, Schwartz, Schwartz, Sivyer, Smith, Talbot, Tanaka, Taylor, Trenholm, Weber, West, Xu, Yonehara, Zhu   +81 more
core   +2 more sources

Alterations in kainate receptor and TRPM1 localization in bipolar cells after retinal photoreceptor degeneration

Frontiers in Cellular Neuroscience, 2015
Photoreceptor degeneration differentially impacts glutamatergic signaling in downstream On and Off bipolar cells. In rodent models, photoreceptor degeneration leads to loss of glutamatergic signaling in On bipolar cells, whereas Off bipolar cells appear ...
Jacqueline eGayet-Primo, Theresa ePuthussery   +1 more
doaj   +1 more source

Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. [PDF]

, 2014
BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene.
Feldheim, David A, Feller, Marla B, Gonzalez, Cristina, Huberman, Andrew D, Sweeney, Neal T, Triplett, Jason W, Wei, Wei   +6 more
core   +2 more sources

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Attenuation of Oxygen-Induced Neovascularization and Inflammation by Neutralizing VEGFA and/or ANG-2 With an Antibody. [PDF]

Genes Cells
The effects of intraocular administration of neutralizing antibodies against VEGFA, ANG‐2, or bispecific to these two factors on pathological findings were examined in the oxygen‐induced retinopathy (OIR) mouse model. The antibody to VEGFA or ANG‐2 attenuated oxygen‐induced neovascularization and inflammation, and the bispecific antibody more ...
Oohashi H, Iwagawa T, Abe H, Kawaji C, Inokuchi Y, Soeda T, Saita K, Aihara M, Watanabe S.   +8 more
europepmc   +2 more sources

Allosteric modulation of retinal GABA receptors by ascorbic acid [PDF]

, 2011
Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells.
Aguayo, Luis G., Calero, Cecilia Ines, Calvo, Daniel Juan, Cid, Gustavo Moraga, Vickers, Evan, von Gersdorff, Henrique   +5 more
core   +1 more source