Results 41 to 50 of about 19,866 (162)

The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases

iScience
Summary: Primary and secondary cone photoreceptor death in retinal degenerative diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa (RP), leads to severe visual impairment and blindness.
Leah Rie Varner, Taro Chaya, Yamato Maeda, Ryotaro Tsutsumi, Shanshan Zhou, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa   +7 more
doaj   +1 more source

Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response

Frontiers in Neurology, 2019
Background: Retinal photoreceptors provide the main stage in the mammalian eye for regulating the retinal illumination through changes in pupil diameter, with a small population of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
Andrew J. Zele, Andrew J. Zele, Prakash Adhikari, Prakash Adhikari, Dingcai Cao, Beatrix Feigl, Beatrix Feigl, Beatrix Feigl   +7 more
doaj   +1 more source

Potential role of Müller cells in the pathogenesis of macropsia associated with epiretinal membrane: a hypothesis revisited [PDF]

International Journal of Ophthalmology, 2017
Pathophysiological explanations for metamorphopsia associated with retinal pathologies generally focus on photoreceptor organization disruption. However, the retinal microarchitecture is complicated, and we hypothesize that other retinal cells may also ...
Ahmet Colakoglu, Solmaz Balci Akar
doaj   +1 more source

Intensity-based optoretinography reveals sub-clinical deficits in cone function in retinitis pigmentosa

Frontiers in Ophthalmology
IntroductionClinical tools have been widely used in the diagnosis, description, and monitoring the progression of retinitis pigmentosa (RP); however, many of these methods have inherently low sensitivity and specificity, and significant photoreceptor ...
Mina Gaffney, Thomas B. Connor, Robert F. Cooper, Robert F. Cooper   +3 more
doaj   +1 more source

Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells

Stem Cell Reports, 2017
Summary: Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retinal degeneration. Transplantation of stem cell-derived L/M-opsin cones, which form 90% of the human cone population, could provide a feasible ...
Emily Welby, Jorn Lakowski, Valentina Di Foggia, Dimitri Budinger, Anai Gonzalez-Cordero, Aaron T.L. Lun, Michael Epstein, Aara Patel, Elisa Cuevas, Kamil Kruczek, Arifa Naeem, Federico Minneci, Mike Hubank, David T. Jones, John C. Marioni, Robin R. Ali, Jane C. Sowden   +16 more
doaj   +1 more source

Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse.

PLoS ONE, 2014
Retinal neurodegeneration is a key component of diabetic retinopathy (DR), although the detailed neuronal damage remains ill-defined. Recent evidence suggests that in addition to amacrine and ganglion cell, diabetes may also impact on other retinal ...
Jose R Hombrebueno, Mei Chen, Rosana G Penalva, Heping Xu   +3 more
doaj   +1 more source

Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa [PDF]

Cell Death Discovery, 2015
AbstractRetinitis pigmentosa (RP) refers to a group of inherited retinal degenerations resulting form rod and cone photoreceptor cell death. The rod cell death due to deleterious genetic mutations has been shown to occur mainly through apoptosis, whereas the mechanisms and features of the secondary cone cell death have not been fully elucidated.
Murakami, Y, Ikeda, Y, Nakatake, S, Tachibana, T, Fujiwara, K, Yoshida, N, Notomi, S, Nakao, S, Hisatomi, T, Miller, J W, Vavvas, DG, Sonoda, KH, Ishibashi, T   +12 more
openaire   +3 more sources

Inner retinal change in a novel rd1-FTL mouse model of retinal degeneration

Frontiers in Cellular Neuroscience, 2015
While photoreceptor loss is the most devastating result of inherited retinal degenerations such as retinitis pigmentosa, inner retinal neurons also undergo significant alteration.
Ursula eGreferath, Emily E Anderson, Andrew I Jobling, Kirstan A Vessey, Gemma eMartinez, Robb U De Iongh, Michael eKalloniatis, Michael eKalloniatis, Erica Lucy Fletcher   +8 more
doaj   +1 more source

Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration [PDF]

Stem Cell Reports, 2017
The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy. Here, we characterize cone differentiation in retinas derived from mouse embryonic stem cells (mESCs). Similar to in vivo development, a temporal pattern of progenitor
Kruczek, Kamil, Gonzalez-Cordero, Anai, Goh, Debbie, Naeem, Arifa, Jonikas, Mindaugas, Blackford, Samuel J.I., Kloc, Magdalena, Duran, Yanai, Georgiadis, Anastasios, Sampson, Robert D., Maswood, Ryea N., Smith, Alexander J., Decembrini, Sarah, Arsenijevic, Yvan, Sowden, Jane C., Pearson, Rachael A., West, Emma L., Ali, Robin R.   +17 more
openaire   +7 more sources

NAALAD2 mutations disrupt the fate of photoreceptor cells and retinal pigment epithelial cells during early retinal development

Pharmacological Research
In recent years, the global incidence of myopia has steadily increased, highlighting the importance of prevention and early intervention, particularly in the absence of effective treatments.
Yuanjie Qian, Jian Gao, Zheming Zhang, Yixuan Chen, Jindi Su, Xing Niu, Kaifeng Zheng, Yantao Bao, Yueyuan Qin, Junge Zheng, Yuankai Yang, Qunyan Wu, Ke Mo, Yantao Wei, Shan Duan   +14 more
doaj   +1 more source