Results 1 to 10 of about 286,988 (401)
Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells [PDF]
PLoS ONE, 2015 Retrograde labelling of retinal ganglion cells with optic nerve transection often leads to degeneration of ganglion cells in prolonged experiments. Here we report that an intact optic nerve could uptake retrograde tracers applied onto the surface of the ...
Liang, YX, So, KF, Yang, J, Yuan, TF
core +15 more sources
High accuracy decoding of dynamical motion from a large retinal population [PDF]
, 2014 Motion tracking is a challenge the visual system has to solve by reading out the retinal population. Here we recorded a large population of ganglion cells in a dense patch of salamander and guinea pig retinas while displaying a bar moving diffusively. We
Berry II, Michael J. +5 more
core +16 more sources
Neurogenesis and Specification of Retinal Ganglion Cells [PDF]
International Journal of Molecular Sciences, 2020 Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated during development, followed by the other retinal cell types. How are retinal progenitor cells (RPCs) able to produce these cell types in a specific and timely order?
Nguyen-Ba-Charvet, Kim Tuyen +1 more
openaire +4 more sources
Encoding surprise by retinal ganglion cells. [PDF]
PLoS Comput Biol, 2022 The efficient coding hypothesis posits that early sensory neurons transmit maximal information about sensory stimuli, given internal constraints. A central prediction of this theory is that neurons should preferentially encode stimuli that are most surprising.
Despotović D +3 more
europepmc +4 more sources
Axonal mitophagy in retinal ganglion cells. [PDF]
Cell Commun SignalNeurons, exhibiting unique polarized structures, rely primarily on the mitochondrial production of ATP to maintain their hypermetabolic energy requirements. To maintain a normal energy supply, mitochondria are transported to the distal end of the axon. When mitochondria within the axon are critically damaged beyond their compensatory capacity, they are
Liang Y +7 more
europepmc +4 more sources
On the Generation and Regeneration of Retinal Ganglion Cells [PDF]
Frontiers in Cell and Developmental Biology, 2020 Retinal development follows a conserved neurogenic program in vertebrates to orchestrate the generation of specific cell types from multipotent progenitors in sequential but overlapping waves. In this program, retinal ganglion cells (RGCs) are the first cell type generated.
Viviane M. Oliveira-Valença +4 more
openaire +5 more sources
Intrinsically Photosensitive Retinal Ganglion Cells [PDF]
Science China Life Sciences, 2010 A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina. These intrinsically photosensitive retinal ganglion cells (ipRGCs) express a photopigment, melanopsin that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor input.
Pickard, Gary E., Sollars, Patricia J.
openaire +8 more sources
Protecting retinal ganglion cells [PDF]
Eye, 2017 Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including ...
Keith R Martin, Tasneem Z Khatib
openaire +3 more sources
Retinal ganglion cells in diabetes [PDF]
The Journal of Physiology, 2008 Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting
Alistair J. Barber, Timothy S. Kern
openaire +3 more sources
The autoregulation of retinal ganglion cell number [PDF]
Development, 2001 ABSTRACT The development of the nervous system is dependent on a complex set of signals whose precise co-ordination ensures that the correct number of neurones are generated. This regulation is achieved through a variety of cues that influence both the generation and the maintenance of neurones during development.
González-Hoyuela, M. +2 more
openaire +3 more sources