Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma [PDF]
Scientific Reports, 2021 Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva +7 more
doaj +2 more sources
Inhibition of BDNF-AS Provides Neuroprotection for Retinal Ganglion Cells against Ischemic Injury. [PDF]
PLoS ONE, 2016 Brain-derived neurotrophic factor (BDNF) protects retinal ganglion cells against ischemia in ocular degenerative diseases. We aimed to determine the effect of BDNF-AS on the ischemic injury of retinal ganglion cells.The levels of BDNF and BDNF-AS were ...
Lifang Xu +4 more
doaj +2 more sources
R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma [PDF]
Neural Regeneration ResearchGlaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use.
Esmahan Durmaz +5 more
doaj +2 more sources
Melanopsin ganglion cells are the most resistant retinal ganglion cell type to axonal injury in the rat retina. [PDF]
PLoS ONE, 2014 We report that the most common retinal ganglion cell type that remains after optic nerve transection is the M1 melanopsin ganglion cell. M1 ganglion cells are members of the intrinsically photosensitive retinal ganglion cell population that mediates non ...
Luis Pérez de Sevilla Müller +3 more
doaj +2 more sources
Diverse Central Projection Patterns of Retinal Ganglion Cells.
Cell Reports, 2017 Emily M. Martersteck +14 more
semanticscholar +2 more sources
Neural Regeneration Research, 2023 [INLINE:1] Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.
Zhe Liu +12 more
doaj +1 more source
Feature Detection by Retinal Ganglion Cells.
Annual Review of Vision Science, 2022 Retinal circuits transform the pixel representation of photoreceptors into the feature representations of ganglion cells, whose axons transmit these representations to the brain.
D. Kerschensteiner
semanticscholar +1 more source
Intrinsically Photosensitive Retinal Ganglion Cells of the Human Retina
Frontiers in Neurology, 2021 Light profoundly affects our mental and physical health. In particular, light, when not delivered at the appropriate time, may have detrimental effects.
L. S. Mure
semanticscholar +1 more source
Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma. [PDF]
PLoS ONE, 2013 Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss.
Pete A Williams +6 more
doaj +1 more source
Retinal Ganglion Cells—Diversity of Cell Types and Clinical Relevance
Frontiers in Neurology, 2021 Retinal ganglion cells (RGCs) are the bridging neurons that connect the retinal input to the visual processing centres within the central nervous system. There is a remarkable diversity of RGCs and the various subtypes have unique morphological features,
U. Kim +3 more
semanticscholar +1 more source