Results 111 to 120 of about 4,628,424 (310)

A comparative study of the potential for human retinal pigment epithelium utilising an embryonic chick model of the phenomenon [PDF]

, 2014
The retinal pigment epithelial (RPE) cells of several species, including: chicken, rat, mouse and newt, have been observed to undergo a phenomenon known as transdifferentiation.
Smart, MJK
core  

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

The optimal synapse for sparse, binary signals in the rod pathway:Neural Computation [PDF]

, 2006
The sparsity of photons at very low light levels necessitates a nonlinear synaptic transfer function between the rod photoreceptors and the rod-bipolar cells.
van Rossum, Mark C W, Paul T. Clark, Mark C. W. van Rossum, Clark, Paul T   +3 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Effects of tACS-Like Electrical Stimulation on Correlated Firing of Retinal Ganglion Cells: Part III

Eye and Brain, 2022
Franklin R Amthor, Christianne E Strang Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, 35294, USACorrespondence: Franklin R AmthorDepartment of Psychology, The University of Alabama at Birmingham, 1300 University Blvd,
Amthor FR, Strang CE
doaj  

Axonal regeneration of retinal ganglion cells: Effect of trophic factors

, 2000
A variety of neurotrophic factors can influence the cell functions of the developing, mature and injured retinal ganglion cells. The discovery that retinal ganglion cell loss can be alleviated by neurotrophic factors has generated a great deal of ...
Yip, HK, Henry K Yip, So, KF, K.-F So
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Melanopsin mediates retrograde visual signaling in the retina.

PLoS ONE, 2012
The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic ...
Dao-Qi Zhang, Michael A Belenky, Patricia J Sollars, Gary E Pickard, Douglas G McMahon   +4 more
doaj   +1 more source

Trainable COSFIRE filters for vessel delineation with application to retinal images [PDF]

, 2015
Retinal imaging provides a non-invasive opportunity for the diagnosis of several medical pathologies. The automatic segmentation of the vessel tree is an important pre-processing step which facilitates subsequent automatic processes that contribute to ...
Petkov, Nicolai, Azzopardi, George
core   +1 more source