Results 121 to 130 of about 238,606 (323)

Optogenetic restoration of retinal ganglion cell activity in the living primate

Nature Communications, 2020
Optogenetic therapies for vision restoration aim to confer intrinsic light sensitivity to retinal ganglion cells when photoreceptors have degenerated and light sensitivity has been irreversibly lost. We combine adaptive optics ophthalmoscopy with calcium
Juliette E. McGregor, Tyler Godat, K. Dhakal, Keith Parkins, Jennifer M. Strazzeri, Brittany A. Bateman, William S. Fischer, David Williams, W. Merigan   +8 more
semanticscholar   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Atoh7-independent specification of retinal ganglion cell identity

Science Advances, 2020
Atoh7 promotes retinal ganglion survival and is not required for specification of most retinal ganglion cells. Retinal ganglion cells (RGCs) relay visual information from the eye to the brain.
Justin Brodie-Kommit, Brian S. Clark, Qing Shi, Fion Shiau, D. W. Kim, Jennifer L. Langel, C. Sheely, Philip A. Ruzycki, Michel Fries, Awais Javed, M. Cayouette, Tiffany M. Schmidt, T. Badea, T. Glaser, Haiqing Zhao, J. Singer, S. Blackshaw, S. Hattar   +17 more
semanticscholar   +1 more source

Biolistic Labeling of Retinal Ganglion Cells

, 2017
Labeling of cellular structures is of fundamental importance in the investigation of diseases of the central nervous system. Biolistic labeling of retinal ganglion cells (RGCs) allows visualization of dendritic and synaptic structures of RGCs in retinal explants from animal models of experimental glaucoma.
Santina, Luca Della, Ou, Yvonne
openaire   +5 more sources

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

A Neural Network Model for the Spatial and Temporal Response of Retinal Ganglion Cells [PDF]

, 1991
This article introduces a quantitative model of early visual system function. The model is formulated to unify analyses of spatial and temporal information processing by the nervous system. Functional constraints of the model suggest mechanisms analogous
Gaudiano, Paolo
core   +1 more source

Optoelectronic synapses based on two‐dimensional transition metal dichalcogenides for neuromorphic applications

InfoScience, EarlyView.
This review first introduces the fundamental concepts of artificial synapses and synaptic plasticity, then discusses the device structures and operation mechanisms of optoelectronic synapses based on two‐dimensional transition metal dichalcogenides, highlights their applications in neuromorphic vision systems and computing, and concludes with key ...
Xiaona Sun, Yifan Hu, Chengbao Jiang, Shengxue Yang   +3 more
wiley   +1 more source

Axonal mitophagy in retinal ganglion cells

Cell Communication and Signaling
Neurons, exhibiting unique polarized structures, rely primarily on the mitochondrial production of ATP to maintain their hypermetabolic energy requirements. To maintain a normal energy supply, mitochondria are transported to the distal end of the axon. When mitochondria within the axon are critically damaged beyond their compensatory capacity, they are
Yang Liang, Yulin Li, Qing Jiao, Muyang Wei, Yan Wang, Aoteng Cui, Zhihui Li, Guangyu Li   +7 more
openaire   +3 more sources

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Scientific Reports, 2017
A photoreceptor cell line, 661W, derived from a mouse retinal tumor that expresses several markers of cone photoreceptor cells has been described earlier. However, these cells can be differentiated into neuronal cells. Here, we report that this cell line
Zuberwasim Sayyad, Kapil Sirohi, Vegesna Radha, Ghanshyam Swarup   +3 more
doaj   +1 more source