Results 161 to 170 of about 286,988 (401)

On the complex dynamics of intracellular ganglion cell light responses in the cat retina [PDF]

open access: yes, 1994
We recorded intracellular responses from cat retinal ganglion cells to sinusoidal flickering lights and compared the response dynamics to a theoretical model based on coupled nonlinear oscillators.
Lankheet, M. J. M.   +2 more
core   +1 more source

The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity

open access: yesAging Cell, EarlyView.
The effect of advancing age and intraocular pressure injury on retinal ganglion cell function and synaptic connectivity. While young mice modulate their synaptic input to recover retinal ganglion cell function following injury, older mice compensate by altering their action potential threshold and axon initial segment (AIS) length to increase intrinsic
Vicki Chrysostomou   +9 more
wiley   +1 more source

Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures

open access: yesJournal of Pharmacological Sciences, 2004
We examined possible involvement of nitric oxide synthase (NOS) on ganglion cell death in explant cultures of neonatal rat retina. Survival of retinal ganglion cells was significantly prolonged by a broad-spectrum NOS inhibitor Nω-nitro-L-arginine ...
Hiroshi Katsuki   +4 more
doaj  

Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions

open access: yesCellular and Molecular Life Sciences, 2020
Marcos L. Aranda, Tiffany M. Schmidt
semanticscholar   +1 more source

Evidence for an additive inhibitory component of contrast adaptation

open access: yes, 2012
The latency of visual responses generally decreases as contrast increases. Recording in the lateral geniculate nucleus (LGN), we find that response latency increases with increasing contrast in ON cells for some visual stimuli.
Gaudry, Kate S., Reinagel, Pamela
core  

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

open access: yesAging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu   +10 more
wiley   +1 more source

Extreme Synergy in a Retinal Code: Spatiotemporal Correlations Enable Rapid Image Reconstruction [PDF]

open access: yesarXiv, 2007
Over the brief time intervals available for processing retinal output, roughly 50 to 300 msec, the number of extra spikes generated by individual ganglion cells can be quite variable. Here, computer-generated spike trains were used to investigate how signal/noise might be improved by utilizing spatiotemporal correlations among retinal neurons ...
arxiv  

DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy

open access: yesAging Cell, EarlyView.
In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding   +8 more
wiley   +1 more source

Activated retinal glia mediated axon regeneration in experimental glaucoma

open access: yesNeurobiology of Disease, 2012
Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina.
Barbara Lorber   +3 more
doaj  

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