Results 181 to 190 of about 15,573 (263)

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Amacrine cell inputs to OFF midget ganglion cells in macaque retina

The Journal of Physiology, EarlyView.
Abstract figure legend The goal of this study was to explain the findings from physiological studies that OFF midget ganglion cells had larger receptive field centers than expected from their dendritic field diameters. First, we confirmed that OFF mRGCs (OFF MGC) receive input from diffuse bipolar cells (DB) as well as OFF midget bipolar cells (FMB ...
David W. Marshak, Andrea S. Bordt, Emma R. Yang, Joel N. Yearick, Marcus Mazzaferri, James A. Kuchenbecker, Judith Mosinger Ogilvie, Sara S. Patterson, Jay Neitz   +8 more
wiley   +1 more source

Discharge patterns of retinal ganglion cells in rodent models of degenerative retinal diseases [PDF]

, 2012
Menzler, Jacob
core  

The what, which, when, why and who of Off responses in the auditory system

The Journal of Physiology, EarlyView.
Abstract figure legend In this article, we will first review ‘What’ different mechanisms are involved in the generation of Off responses at the sub‐cortical and cortical level of the auditory system. Then, we evaluate ‘Which’ stimulus properties elicit Off responses at the different levels of the auditory system.
Jean‐Marc Edeline, Robert C. Liu
wiley   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

Swallowing and Communication in Cockayne Syndrome: Clinical Characteristics and Management

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1465-1478, July 2026.
ABSTRACT Cockayne syndrome (CS) is an ultrarare genetic disorder associated with genes encoding proteins involved in DNA repair. The clinical course of CS involves neurodevelopmental and neurodegenerative features, including swallowing and communication impairments.
Abigail M. Spoden, Katlyn E. McGrattan, Peter B. Kang   +2 more
wiley   +1 more source

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12 ‐Related Developmental Disorders

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1619-1650, July 2026.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Disrupted Vestibular Nuclei Neuron Development in a Chick Model for Congenital Vestibular Disorders

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Children with syndromic, congenital vestibular disorders (CVDs) form a sac‐like inner ear with missing or truncated semicircular canals and experience delayed motor development with lifelong challenges to maintain posture and balance. How the abnormal inner ear affects downstream central vestibular neural circuitry has not been investigated ...
Elizabeth B. Bogin, Rossella Conti, Kathleen Gallagher, Kaya Oguz, Anastas Popratiloff, Kenna D. Peusner   +5 more
wiley   +1 more source

Microglial Pruning of Excitatory Synapses in the Hippocampus Is Complement C3‐Independent in Physiological and Neuroinflammatory States

Glia, Volume 74, Issue 7, July 2026.
In development, microglia engulfment of hippocampal excitatory synapses is unperturbed in C3‐lacking mice. Peripheral inflammation induces a neuroinflammatory phenotype and synapse loss in the hippocampus independent of complement cascade activation. ABSTRACT A key feature of brain development is the refinement of exuberant synapses, known as synapse ...
Eric W. Salter, Ashish Kadia, Lijia Zhang, Jonathan S. Thacker, Sun‐Lim Choi, Liam T. Ralph, Gang Lei, Fuzi Jin, John Georgiou, Graham L. Collingridge   +9 more
wiley   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source