Results 181 to 190 of about 60,940 (264)

CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang, Xinbo Ji, Han Yu, Jingwen Xu, Yu Wang, Ping Sun, Yingxin Wang, Yao Tang, Zexin Zhan, Yichang Jiao, Didi Shan, Pengfei Lin, Dong‐dong Wang, Yuying Zhao, Xianyang Liu, Chuanzhu Yan, Jianqiao Li, Mingfeng Li, Fuchen Liu, Shengping Hou   +19 more
wiley   +1 more source

Photodisruption of the Inner Limiting Membrane Promotes Retinal Engraftment of Stem-Cell Derived Retinal Ganglion Cells. [PDF]

Invest Ophthalmol Vis Sci
De Coster E, De Clerck K, De Clercq C, Li W, Punj D, Vanmeerhaeghe B, Verdonck J, De Smedt S, Braeckmans K, Hadady H, Remaut K, Johnson TV, Peynshaert K.   +12 more
europepmc   +1 more source

The retinal ganglion cells in metabolic syndrome

Annals of Translational Medicine
Pappelis, Konstantinos, Chatziralli, Irini, Georgiadis, Odysseas, Theodossiadis, George P., Theodossiadis, Panagiotis G., Jansonius, Nomdo M.   +5 more
openaire   +2 more sources

Moutan Cortex Extract Mediates Diabetic Retinopathy by Blocking the ROS‑Triggered HIF‐1α/VEGF Axis in Retinal Pigment Epithelial Cells

eFood, Volume 7, Issue 4, August 2026.
Schematic diagram of the mechanism by which Moutan Cortex extract (MCE) ameliorates DR. MCE alleviates retinal structural damage and reduces neovascular lesions by downregulating the ROS/HIF‐1α/VEGF signaling axis. ABSTRACT Moutan Cortex is a functional food ingredient with multiple health benefits, but its effects on diabetic retinopathy (DR) remain ...
Mei‐rong Li, Xian‐yi Zhang, Wan‐ying Zhang, Nan Chen, Wei‐wei Lv, Tian‐yu Liu, Xu Guo, Ying‐ying Chen, Meng‐qi Zhang, Shu‐tao Sun, Mu‐xuan Wang, Qi‐dong Ren, Chao Liu, Jin‐yue Sun   +13 more
wiley   +1 more source

Overexpression or Activation of Potassium Channel TASK-3 Protects Retinal Ganglion Cells and Restores Visual Function in Optic Nerve Crush. [PDF]

Invest Ophthalmol Vis Sci
Zhang J, Chen X, Ji J, Chen P, Yao J, Jiang R, Liu L, Wen X.   +7 more
europepmc   +1 more source

Bio‐inspired artificial retina with receptive fields for in‐sensor multiply‐and‐accumulate operations

InfoMat, Volume 8, Issue 8, August 2026.
We developed a bio‐inspired artificial retina in which curved artificial receptive fields composed of perovskite photoconductors perform multiply‐and‐accumulate operations through in‐sensor computing. This architecture simultaneously realized the structural efficiency of human eyes (compact single‐lens imaging system) and functional advantages of ...
Jisang Ha, Jinsung Mok, Jong Ik Kwon, Eungseon Yeon, Jeong Jin Kim, Gil Ju Lee, Do Kyung Hwang, Changsoon Choi, Dae‐Hyeong Kim   +8 more
wiley   +1 more source

Epothilone B stabilizes microtubules via Tau to protect retinal ganglion cells and promote axon regeneration. [PDF]

Cell Commun Signal
Liang Y, Chi J, Sun YJ, Li YZ, Li YL, Li GY.   +5 more
europepmc   +1 more source

3D‐Printed Electroanatomic Twins of Cadaveric Cochleae: A Platform for Cochlear Implant Testing

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objectives Cochlear implants (CIs) can restore hearing to individuals with severe deafness, yet clinical outcomes vary widely because it remains difficult to predict how electrical currents interact with the unique anatomy of each cochlea. A central challenge in auditory rehabilitation is the lack of experimental systems that capture both the ...
Chloe Swords, Iwan Vaughan Roberts, Sita Tarini Clark, Filip Hrncirik, Botian Huang, François Guérit, Cecilia Brassett, Manohar L. Bance   +7 more
wiley   +1 more source

Effects of a ROCK Inhibitor on Retinal Ganglion Cells In Vivo and In Vitro. [PDF]

J Clin Med
Chen W, Iizuka Y, Mabuchi F, Kashiwagi K.   +3 more
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source