Results 191 to 200 of about 60,940 (264)

Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway. [PDF]

Hum Cell
Li Q, Ge W, Zhang Y, Xu Q, Xu J, Zhang Y, Guo X, Sheng W, Zhu L.   +8 more
europepmc   +1 more source

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source

Human pluripotent stem cell-derived retinal ganglion cells: advances in differentiation and translational applications. [PDF]

Mol Med
Ma JYW, Daniszewski M, Pébay A.
europepmc   +1 more source

Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy

Optometry and Vision Science, Volume 103, Issue 8, August 2026.
ABSTRACT Purpose To highlight retinal ischemia as an important component of diabetic retinopathy (DR) pathogenesis, a significant prognostic factor, and a driver of various DR complications, including neovascularization. We aim to describe the main features of ischemic areas that can be identified through fundoscopy, color fundus photography, optical ...
Marina Guro, Henrietta Wang, Jack Phu, Kaitlyn A. Sapoznik, Hamza Shah, Maggie L. Zhang, Michael Kalloniatis   +6 more
wiley   +1 more source

A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness. [PDF]

J Gen Physiol
Horie S, Sakuta K, Tada K, Tokumoto H, Nishimoto T, Kitano K, Tachibana M, Koike C.   +7 more
europepmc   +1 more source

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić, Marko Skelin, Yun Wah Lam, Almir Fajkić, Bruna Perkov‐Stipičin, Rossana Roncato, Ivan Krečak, Marko Lucijanić   +7 more
wiley   +1 more source

Magnetically guided neurite outgrowth modulated by PIEZO1 in hiPSC-derived retinal ganglion cells. [PDF]

Mater Today Bio
Chen IT, Chu PH, Hu SH, Chen SK, Chiao CC, Yang TC.   +5 more
europepmc   +1 more source

Injectable Artificial Photoreceptors: STEM Cell Functional Integration and in vivo Electrophysiological Validation in Retinal Degeneration Models

Small Science, Volume 6, Issue 8, August 2026.
Artificial photoreceptors are engineered to efficiently absorb light, with the strongest sensitivity in the green region of the visible spectrum. Upon illumination, they generate electrical signals that activate retinal ganglion cells, which are typically unaffected by disease, enabling transmission of visual information to the brain.
Afshin Izadian, Ali Torkashvand, Benjamin Allan McCall, Yong Gao, Christine M. Taylor, Fateme Karimi Hafshejani, Arupratan Das, Michelle L. Surma, Sunland Gong, Amir Reza Hajrasouliha   +9 more
wiley   +1 more source

Scutellarin Protects Retinal Ganglion Cells in Glaucoma by Targeting the Hsp90aa1-MAPK Pathway to Inhibit Apoptosis. [PDF]

Invest Ophthalmol Vis Sci
Su JZ, Wang J, Gao ZL, Ding L, Xia XB.
europepmc   +1 more source

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, Volume 7, Issue 4, August 2026.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source