Results 191 to 200 of about 109,464 (277)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Overexpression or Activation of Potassium Channel TASK-3 Protects Retinal Ganglion Cells and Restores Visual Function in Optic Nerve Crush. [PDF]

Invest Ophthalmol Vis Sci
Zhang J, Chen X, Ji J, Chen P, Yao J, Jiang R, Liu L, Wen X.   +7 more
europepmc   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Photodisruption of the Inner Limiting Membrane Promotes Retinal Engraftment of Stem-Cell Derived Retinal Ganglion Cells. [PDF]

Invest Ophthalmol Vis Sci
De Coster E, De Clerck K, De Clercq C, Li W, Punj D, Vanmeerhaeghe B, Verdonck J, De Smedt S, Braeckmans K, Hadady H, Remaut K, Johnson TV, Peynshaert K.   +12 more
europepmc   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Tunable dual-AAV sparse labeling of PV⁺ retinal ganglion cells enables single-neuron projection by fMOST. [PDF]

Front Neural Circuits
Zhou L, Tan G, Li Y, Yuan M, Jin S, Zhang W, Wang Q, Shen Y.   +7 more
europepmc   +1 more source

Mapping Escolar (Lepidocybium flavobrunneum) in Motion: Oceanographic Forces Shaping Its Habitat in the Southwestern South Atlantic, With Insights From Fishers' Perceptions

Fisheries Oceanography, Volume 35, Issue 3, Page 445-461, May 2026.
ABSTRACT Lepidocybium flavobrunneum [Smith, 1843], commonly known as escolar, is a large pelagic species, important for global and local fisheries, particularly in the southwestern South Atlantic Ocean (SWAO), where it constitutes a significant portion of the catch.
Lucas Rodrigues, Maria Grazia Pennino, Paul Gerhard Kinas, David Conesa, Alba Fuster‐Alonso, Andrés Domingo, Rodrigo Forselledo, Federico Mas, Bruno Mourato, Rodrigo Sant'Ana, Vinni Santos Thykjaer, Raquel Virginia Marquez Marquez, Abner Ventura Alves, Mariano Cabanillas‐Torpoco, Rafael Schroeder, Luis Gustavo Cardoso   +15 more
wiley   +1 more source

OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies. [PDF]

Commun Biol
Wang Q, Wang Y, Jiang YDD, Donahue R, Cao G, Yan W, Guo H, Li Z, Liang J, Hao J, Lu Y, Bei F, Wang Q, Tian F.   +13 more
europepmc   +1 more source

Reversible Neurological Manifestations Preceding Biochemical Deterioration in Postpartum HELLP Syndrome—A Case Report and Literature Review

The Journal of Clinical Hypertension, Volume 28, Issue 5, May 2026.
ABSTRACT Posterior reversible encephalopathy syndrome (PRES) is a rare but severe neurological complication associated with hypertensive disorders of pregnancy and HELLP syndrome. We report a postpartum case in which neurological manifestations preceded the full biochemical expression of HELLP syndrome. A 22‐year‐old primigravida was admitted at 36 + 0
Dario Colacurci, Stefano Raffaele Giannubilo, Laura Sarno, Caterina Fulgione, Laura Letizia Mazzarelli, Angelo Sirico, Maria Liberata Meccariello, Andrea Albanese, Dayana Quintili, Irene Lubinski, Mario Ascione, Carla Riccardi, Giorgia D'Apice, Mariarosaria Motta, Sara Iannantuoni, Chiara Murolo, Giuseppe Bifulco, Costantino Di Carlo, Andrea Ciavattini, Giuseppe Maria Maruotti   +19 more
wiley   +1 more source

Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway. [PDF]

Hum Cell
Li Q, Ge W, Zhang Y, Xu Q, Xu J, Zhang Y, Guo X, Sheng W, Zhu L.   +8 more
europepmc   +1 more source