Results 11 to 20 of about 197,248 (310)
PTEN Expression Regulates Gap Junction Connectivity in the Retina
Frontiers in Neuroanatomy, 2021 Manipulation of the phosphatase and tensin homolog (PTEN) pathway has been suggested as a therapeutic approach to treat or prevent vision loss due to retinal disease.
Ashley M. Chen +7 more
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Nature Communications, 2022 The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here,
Jérémie Sibille +7 more
semanticscholar +1 more source
Neural Regeneration Research, 2023 Ras homolog enriched in brain (Rheb) is a small GTPase that activates mammalian target of rapamycin complex 1 (mTORC1). Previous studies have shown that constitutively active Rheb can enhance the regeneration of sensory axons after spinal cord injury by ...
Jikuan Jiang +7 more
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Clinical electrophysiology of the optic nerve and retinal ganglion cells
Eye, 2021 Clinical electrophysiological assessment of optic nerve and retinal ganglion cell function can be performed using the Pattern Electroretinogram (PERG), Visual Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other more specialised
O. Marmoy, S. Viswanathan
semanticscholar +1 more source
In vivo chromatic and spatial tuning of foveolar retinal ganglion cells in Macaca fascicularis.
PLoS ONE, 2022 The primate fovea is specialized for high acuity chromatic vision, with the highest density of cone photoreceptors and a disproportionately large representation in visual cortex.
Tyler Godat +10 more
doaj +2 more sources
Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells. [PDF]
PLoS ONE, 2015 Retrograde labelling of retinal ganglion cells with optic nerve transection often leads to degeneration of ganglion cells in prolonged experiments. Here we report that an intact optic nerve could uptake retrograde tracers applied onto the surface of the ...
Yu-Xiang Liang +3 more
doaj +1 more source
Lepidium sativum as candidate against excitotoxicity in retinal ganglion cells
Translational Neuroscience, 2021 Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. Retinal ganglion cell degeneration causes severe blindness since visual signals from the eye to the brain are conducted only through ...
Al-Dbass Abeer +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Radiation retinopathy (RR) is a common complication following radiation therapy of globe, head, and neck malignancies, and is characterized by microangiopathy, neuroretinopathy, and the irreversible loss of visual function. To date, there is no effective
Siyu Chen +21 more
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Glial metabolic alterations during glaucoma pathogenesis
Frontiers in Ophthalmology, 2023 Glaucoma is the leading cause of irreversible blindness. Current treatment options are limited and often only slow disease progression. Metabolic dysfunction has recently been recognized as a key early and persistent mechanism in glaucoma pathophysiology.
Anne Rombaut +3 more
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VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury
Molecular Therapy: Methods & Clinical Development, 2020 In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which ...
Annabelle Schlüter +4 more
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