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Towards Retinal Ganglion Cell Regeneration
Regenerative Medicine, 2012Traumatic optic nerve injury and glaucoma are among the leading causes of incurable vision loss across the world. What is worse, neither pharmacological nor surgical interventions are significantly effective in reversing or halting the progression of vision loss.
Huasong, Gao +7 more
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1988
Ganglion cells typically make up the innermost layer of the vertebrate retina. They are the only cells with axons that leave the eye. These axons form the optic nerve. Ganglion cell dendrites ramify in the inner nuclear layer, where they are postsynaptic to bipolar cells, which provide a direct input pathway from the outer plexiform layer, and to ...
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Ganglion cells typically make up the innermost layer of the vertebrate retina. They are the only cells with axons that leave the eye. These axons form the optic nerve. Ganglion cell dendrites ramify in the inner nuclear layer, where they are postsynaptic to bipolar cells, which provide a direct input pathway from the outer plexiform layer, and to ...
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Correlated firing of retinal ganglion cells
Trends in Neurosciences, 1989Even in the absence of visual stimulation, retinal ganglion cells have a substantial maintained discharge. This maintained discharge is not generated independently within each ganglion cell, because the unstimulated activity of two neighboring ganglion cells can be remarkably correlated.
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Classification of turtle retinal ganglion cells
Journal of Neurophysiology, 19891. Receptive fields of 78 retinal ganglion cells were analyzed for their responses to moving and stationary lights that were presented under a variety of stimulus conditions. All cells were sensitive to moving stimuli, and their receptive fields often comprised excitatory and inhibitory sub-regions. 2.
A M, Granda, J E, Fulbrook
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'Refracting' a Single Retinal Ganglion Cell
Archives of Ophthalmology, 1971The response characteristics of retinal ganglion cells to focused and blurred imagery and three interdependent response criteria, measured at the ganglion cell level, are used for the neurophysiological estimate of refractive error.
R M, Hill, H, Ikeda
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Concerted Signaling by Retinal Ganglion Cells
Science, 1995To analyze the rules that govern communication between eye and brain, visual responses were recorded from an intact salamander retina. Parallel observation of many retinal ganglion cells with a microelectrode array showed that nearby neurons often fired synchronously, with spike delays of less than 10 milliseconds.
M, Meister, L, Lagnado, D A, Baylor
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Diacylglycerol Signaling in Retinal Ganglion Cells
With impaired retinal ganglion cell (RGC) function and eventual RGC death, there is a heightened risk of experiencing glaucoma-induced blindness or other optic neuropathies. Poor RGC efficiency leads to limited transmission of visual signals between the retina and the brain by RGC axons.Ishan, Chaplot +3 more
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Retinal Ganglion Cell Shrinkage in Glaucoma
Journal of Glaucoma, 2002There has been some debate concerning the selective loss of retinal ganglion cells belonging to the magnocellular pathway in early glaucoma. Although histologic studies of retinal ganglion cells in experimental and human glaucoma have suggested selective loss of the larger cells and, by implication, selective damage to the magnocellular pathway, this ...
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Classifying and Comparing Retinal Ganglion Cells
Brain, Behavior and Evolution, 2008A simple numerical method is suggested for comparing the types of ganglion cell in the cat, monkey, rabbit and pigeon, using the W,X,Y classification as a basis.
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Rodent Retinal Ganglion Cell Cultures
2012Central neurons lose the ability for axonal regrowth during development and typically do not regenerate their axons following axotomy once they become mature unless given a growth-permissive environment, for example, a peripheral nerve graft. Retinal ganglion cells (RGCs) of the optic nerve represent a highly useful cell model for the study of ...
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