Results 21 to 30 of about 197,248 (310)
Investigative Ophthalmology and Visual Science, 2020 Purpose To determine whether priming of bone marrow mesenchymal stem cells (MSCs) by signals from injured retina, particularly tumor necrosis factor α (TNFα), increase their exosomes’ neuroprotective efficacy on retinal ganglion cells (RGCs).
B. Mead +4 more
semanticscholar +1 more source
Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. [PDF]
PLoS ONE, 2012 While the essential role of bone morphogenetic protein (BMP) signaling in nervous system development is well established, its function in the adult CNS is poorly understood.
Yumi Ueki, Thomas A Reh
doaj +1 more source
Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma
Neural Regeneration Research, 2021 The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
doaj +1 more source
Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. [PDF]
PLoS ONE, 2013 Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown.
Jun Yu +5 more
doaj +1 more source
Neurogenesis and Specification of Retinal Ganglion Cells
International Journal of Molecular Sciences, 2020 Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated during development, followed by the other retinal cell types.
K. Nguyen-Ba-Charvet, Alexandra Rebsam
semanticscholar +1 more source
Neural Regeneration Research, 2016 Bone marrow mesenchymal stem cells can reduce retinal ganglion cell death and effectively prevent vision loss. Previously, we found that during differentiation, female rhesus monkey bone marrow mesenchymal stem cells acquire a higher neurogenic potential
Jing Yuan, Jian-xiong Yu
doaj +1 more source
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]
PLoS Genetics, 2005 In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby +6 more
doaj +2 more sources
Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies
Biology, 2021 Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous ...
Yue Hu +3 more
doaj +1 more source
The functional diversity of retinal ganglion cells in the mouse
Nature, 2015 In the vertebrate visual system, all output of the retina is carried by retinal ganglion cells. Each type encodes distinct visual features in parallel for transmission to the brain. How many such ‘output channels’ exist and what each encodes are areas of
T. Baden +5 more
semanticscholar +1 more source
Folia Histochemica et Cytobiologica, 2012 Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 ...
Joanna Reszeć +3 more
doaj +1 more source