The FASEB Journal, Volume 40, Issue 7, 15 April 2026.We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala +3 more
wiley +1 more source
Irigenin Modulates BL-Induced Pyroptosis in Retinal Pigment Epithelial Cells Through p38 MAPK and NFκB Pathways. [PDF]
J Biochem Mol ToxicolSu IL +9 more
europepmc +1 more source
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, Volume 13, Issue 19, 2 April 2026.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
Protocol for the differentiation of induced pluripotent stem cells into retinal pigment epithelial cells. [PDF]
STAR ProtocZorin M +2 more
europepmc +1 more source
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Geographic retinal dysplasia is inherited in the Cavalier King Charles Spaniel. This detailed multimodal imaging description of an affected dog demonstrates that the presumed dysplastic retina area consists of a thickened retinal nerve fiber layer, similar to plaque‐like lesions previously reported in other breeds, such as the Labrador ...
Shaile Gehrke +4 more
wiley +1 more source
Gypenosides mitigate acrylamide-induced oxidative stress, inflammation and lipid metabolic dysregulation in retinal pigment epithelial cells and in zebrafish embryos. [PDF]
Mol Biol RepTchiveleketea GM +5 more
europepmc +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen +5 more
wiley +1 more source
Hydrogen‐Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy
Journal of Diabetes, Volume 18, Issue 4, April 2026.The combination of VSD and hydrogen‐rich saline is used to treat diabetic foot ulcers. In vitro and in vivo studies reveal that hydrogen‐enrich hyaluronic acid dressings enhance skin fibroblast repair ability by regulating mitophagy via the SIRT3 and its downstream signaling pathways, ultimately accelerating wound healing in diabetic foot ulcers ...
Ziyu Xu +8 more
wiley +1 more source
Protective Effect of Curcumin in Oxidative Stress-Induced Injury on Retinal Pigment Epithelial Cells. [PDF]
J Clin MedYu HS, Cho H, Shin YU, Hong EH, Koh SH.
europepmc +1 more source
45Ca uptake by retinal pigment epithelial cells.
Investigative ophthalmology & visual science, 1989 Uptake of 45Ca was studied in isolated frog retinal pigment epithelial cells. 45Ca accumulation was found to be a saturable, temperature-dependent event. Kinetic analysis of this accumulation revealed two transport systems with apparent km of 2.0 and 0.3 mM.
openaire +1 more source