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The cone visual cycle and its disorders: insights from zebrafish [PDF]
Frontiers in Molecular NeuroscienceContinuous vision relies on the recycling of visual pigment chromophore, which is photoisomerized during the process of vision. In vertebrates, this recycling is mediated by a complex network of biochemical reactions distributed across different cell ...
Ioanna S. Koutroumpa +1 more
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Current Issues in Molecular Biology, 2022 RPE65, an abundant membrane-associated protein present in the retinal pigment epithelium (RPE), is a vital retinoid isomerase necessary for regenerating 11-cis-retinaldehyde from all-trans retinol in the visual cycle.
Mirjana Bjeloš +4 more
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PLoS ONE, 2022 The visual cycle refers to a series of biochemical reactions of retinoids in ocular tissues and supports the vision in vertebrates. The visual cycle regenerates visual pigments chromophore, 11-cis-retinal, and eliminates its toxic byproducts from the ...
Yuhong Wang +8 more
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Histopathology of Pigment dispersion syndrome and glaucoma
Oman Journal of Ophthalmology, 2023 Pigment dispersion syndrome (PDS) can have varied manifestations. Anterior and posterior segment involvement by dispersed pigments was documented in gross pathology and by staining under microscopy.
Dipankar Das +5 more
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The Physical Mechanism for Retinal Discrete Dark Noise: Thermal Activation or Cellular Ultraweak Photon Emission? [PDF]
PLoS ONE, 2016 For several decades the physical mechanism underlying discrete dark noise of photoreceptors in the eye has remained highly controversial and poorly understood.
Vahid Salari +4 more
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Retinoids in the visual cycle: role of the retinal G protein-coupled receptor
Journal of Lipid Research, 2021 Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration.
Elliot H. Choi +4 more
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Retinal Pigment Epithelium Tear [PDF]
Current Ophthalmology Reports, 2014 Retinal pigment epithelium tear is a potentially vision threatening complication of retinal pigment epithelial detachment associated with neovascular age-related macular degeneration. Retinal pigment epithelium tear has been reported to occur spontaneously and after treatment with anti-vascular growth endothelial factor agents.
Aleksandra V, Rachitskaya +1 more
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Frontiers in Nutrition, 2023 IntroductionMedicine faces nowadays the trend of increasing life expectancy of human population, with the resulting increase of degenerative age related diseases prevalence, combined with the risks of less tempered sun radiations environment exposure ...
Sanda Jurja +5 more
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Preclinical pharmacology of a lipophenol in a mouse model of light-induced retinopathy
Experimental and Molecular Medicine, 2020 Experimental & Molecular Medicine: Vision loss: Shedding light on how to prevent retinal damage Treating retinal damage in both aging and young patients might now be easier, thanks to treatment with a lipophenol, an omega-3 fatty acid linked to an ...
Nicolas Taveau +10 more
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Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model. [PDF]
PLoS ONE, 2016 We present a multi-functional optical coherence tomography (OCT) imaging approach to study retinal changes in the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model with a threefold contrast.
Marco Augustin +9 more
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