Results 91 to 100 of about 88,526 (282)

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

RB1 in cancer: Different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis. [PDF]

, 2013
Loss of RB1 gene is considered either a causal or an accelerating event in retinoblastoma. A variety of mechanisms inactivates RB1 gene, including intragenic mutations, loss of expression by methylation and chromosomal deletions, with effects which are ...
Abramson, Adams, Adon, Akin, Albertson, Alonso, Aoki, Arima, Arima, Attwooll, Bamne, Barbie, Berman, Boehm, Bova, Bracken, Brehm, Bremner, Canhoto, Chan, Chatterjee, Chellappan, Chen, Chin, Chong, Chow, Classon, Claudio, Claudio, Cobrinik, Collins, Conkrite, Corson, D'Andrilli, D'Andrilli, D'Anneo, D'Urso, De Blasio, De Falco, Dean, DeCaprio, Deng, Dimaras, Dowdy, Drago-Ferrante, Dunaief, Dunn, Dyson, Falls, Feugeas, Friend, Ganguly, Gaubatz, Gaubatz, Genovese, Giuliano, Godbout, Gouyer, Haller, Hansen, He, Henley, Hiebert, Higgins, Hijmans, Hill, Hong, Hu, Hurst, Indovina, Infante, Jean, Khatib, Kim, Knudsen, Knudson, Kothandaraman, Lalande, Lammens, Lavia, Lee, Lees, Li, Litovchick, Liu, Logan, Macpherson, Maeta, Masciullo, Moberg, Modi, Monteiro, Moon, Moran, Na-Hye, Neganova, Nielsen, Oberley, Parisi, Perrone, Pipinikas, Plisiecka-Hałasa, Pohlers, Pusapati, Rangarajan, Reimer, Richter, Rizzolio, Robanus-Maandag, Sage, Sellers, Sharpless, Shi, Simin, Swerdlow, Szabova, Teissier, Valverde, Vogel, Wang, Weinberger, Wenzel, Westendorp, Williams, Williams, Williams, Worku, Wu, Wu, Wölfel, Xie, Xiong, Xue, Yokota   +133 more
core   +1 more source

Supplementary Figure Legends 1-4 from Retinoblastoma Family Proteins Have Distinct Functions in Pulmonary Epithelial Cells <i>In vivo</i> Critical for Suppressing Cell Growth and Tumorigenesis [PDF]

, 2023
David S. Simpson, Nicole A. Mason-Richie, Caitlin A. Gettler, Kathryn A. Wikenheiser‐Brokamp   +3 more
openalex   +1 more source

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization

eLife, 2013
Skeletal muscle degeneration is a complication arising from a variety of chronic diseases including advanced cancer. Pro-inflammatory cytokine TNF-α plays a pivotal role in mediating cancer-related skeletal muscle degeneration.
Keigo Araki, Keiko Kawauchi, Hiroaki Hirata, Mie Yamamoto, Yoichi Taya   +4 more
doaj   +1 more source

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus [PDF]

, 2011
Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication ...
Ali, Binda, Campbell, Campbell, Caplan, Cotsiki, Côté-Martin, DeCaprio, Dilworth, Felici, Feng, Flinn, Hakki, Houben, Jennifer Hein, Lane, Laude, Li, Liang, Linzer, Mannová, Nakamura, Nakamura, Ole V. Gjoerup, Pallas, Patrick S. Moore, Pelkmans, Per H. Basse, Peralta, Pipas, Poupon, Price, Qian, Richardson, Schowalter, Shuda, Shuda, Simon C.W. Richardson, Srinivasan, Sukarieh, Tuna Toptan, Whitman, Wrana, Wurmser, Xi Liu, Yuan Chang   +45 more
core   +2 more sources

Meropenem‐Heparin Lock Therapy for Ochrobactrum intermedium Catheter‐Related Bloodstream Infection in a Pediatric Hemodialysis Patient: A Case Report and Literature Review

Hemodialysis International, EarlyView.
ABSTRACT Background In pediatric hemodialysis patients with exhausted vascular access, managing rare pathogens like Ochrobactrum intermedium is challenging, often posing a dilemma between catheter removal and salvage attempts. There are few reports on the supported viability of meropenem‐heparin lock therapy for this purpose in pediatric patients. Case
Mônica Cristina Dutra Rodrigues, Fernanda Teixeira Sillva, Anderson Pereira de Oliveira, Yeo Jim Kinoshita Moon, Jhohann Richard de Lima Benzi   +4 more
wiley   +1 more source

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. [PDF]

, 2017
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by
Bisetto, Sara, Casimiro, Mathew C., Di Rocco, Agnese, Disante, Gabriele, Jiao, Xuanmao, Kusminski, Christine M., Li, Zhiping, Loro, Emanuele, Ly, Daniel, Pestell, Richard, Pestell, Timothy G., Pupo, Claudia, Scherer, Philipp E., Seifert, Erin L., Shen, Che-Hung, Velasco-Velázquez, Marco A., Wang, Chenguang, Zheng, Bin   +17 more
core   +1 more source

RB1 inactivation in cutaneous carcinomas

Histopathology, EarlyView.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. [PDF]

, 2018
Purpose: The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC).
Addya, Sankar, Bhardwaj, Anshul, Birbe, Ruth, Chellappagounder, Thangavel, Den, Robert B., Dicker, Adam P., Ertel, Adam, Ettickan, Boopathi, Haber, Alex, Knudsen, Karen E., Liu, Yi, McNair, Christopher, Perepelyuk, Maryna, Salvino, Joseph M., Shoyele, Sunday   +14 more
core   +1 more source