Results 1 to 10 of about 5,117,545 (235)
Retinoic acid signaling pathways [PDF]
Development, 2019 Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes.
N. Ghyselinck, G. Duester
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International Journal of Applied and Basic Medical Research, 2017 Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have
Dipankar Mondal +2 more
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Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. [PDF]
Haematology and blood transfusion, 1988 Twenty-four patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (45 to 100 mg/m2/day). Of these, eight cases had been either nonresponsive or resistant to previous chemotherapy; the other 16 cases were previously ...
Meng-er Huang +7 more
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Journal of Lipid Research, 1985 An assay based on negative ion chemical ionization mass spectrometry has been developed to quantify retinoic acid in plasma or serum. The lower limit of detection is 75 pg (240 fmol); normal values of retinoic acid can be determined on as little as 40 ...
J L Napoli +4 more
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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.
Proceedings of the National Academy of Sciences of the United States of America, 1980 The HL-60 cell line, derived from a patient with acute promyelocytic leukemia, proliferates continuously in suspension culture and consists predominantly (greater than 90%) of promyelocytes.
T. Breitman +3 more
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Origin of some derivatives of retinoic acid found in rat bile
Journal of Lipid Research, 1968 After the intraportal injection of retinoic acid-15-14C into rats, all-trans methyl retinoate, a cis isomer of methyl retinoate, retinoyl β-glucurono-γ-lactone, retinoic acid, and retinoyl β-glucuronide were isolated from methanol extracts of rat bile by
Kenneth Lippel, James Allen Olson
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Retinoic acid and cancer treatment
BioMedicine, 2014 Retinoic acid which belongs to the retinoid class of chemical compounds is an important metabolite of vitamin A in diets. It is currently understood that retinoic acid plays important roles in cell development and differentiation as well as cancer ...
Mei-Chih Chen +3 more
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Bibliometric analysis of research on retinoic acid in the field of kidney disorders [PDF]
Frontiers in PharmacologyRetinoic acid is an active metabolite with significant physiological functions in human development, immunity, vision, and skin health. In recent years, research on retinoic acid in the field of kidney disorders has been increasing gradually.
Yu Liu +12 more
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Retinoic Acid and Its Derivatives in Skin
Cells, 2020 The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański +8 more
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Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues
Scientific Reports, 2021 Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting adenoma and ...
Francesca Pecori Giraldi +4 more
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