Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues
Scientific Reports, 2021 Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting adenoma and ...
Francesca Pecori Giraldi +4 more
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Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. [PDF]
PLoS ONE, 2012 The retinoids, the natural or synthetic derivatives of Vitamin A (retinol), are essential for the normal development of prostate and have been shown to modulate prostate cancer progression in vivo as well as to modulate growth of several prostate cancer ...
Linda Kelsey +4 more
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Microbial Production of Bioactive Retinoic Acid Using Metabolically Engineered Escherichia coli
Microorganisms, 2021 Microbial production of bioactive retinoids, including retinol and retinyl esters, has been successfully reported. Previously, there are no reports on the microbial biosynthesis of retinoic acid.
Minjae Han, Pyung Cheon Lee
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The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer [PDF]
, 2014 Peer reviewedPublisher ...
Alnabulsi, Ayham +5 more
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Journal of Materials Science: Materials in Medicine, 2021 Despite recent advances in the treatment of human colon cancer, the chemotherapeutic efficacy against colon cancer is still unsatisfactory. The complexity in colorectal cancer treatment leads to new research in combination therapy to overcome multidrug ...
Narayan Ture +2 more
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Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells [PDF]
, 2020 Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells.
Bilip, Maja +11 more
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Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. [PDF]
, 2020 This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis
Roberts, C
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Metabolism of all-trans-retinoic acid by cultured human epidermal keratinocytes
Journal of Lipid Research, 1997 The uptake and metabolism of exogenous all-trans-retinoic acid by human epidermal keratinocytes in submerged culture was examined. Retinoic acid presented to keratinocytes in physiological form bound to albumin was rapidly taken up.
R K Randolph, M Simon
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Frontiers in Cell and Developmental Biology, 2022 Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic acid treatment is part of the maintenance
Roshna Lawrence Gomez +9 more
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Journal of Lipid Research, 1992 In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in ...
Riaz-ul-Haq, F Chytil
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