Results 91 to 100 of about 357,868 (360)

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function

BMC Genomics, 2018
Background Development of the face and mouth is orchestrated by a large number of transcription factors, signaling pathways and epigenetic regulators.
Stacey E. Wahl, Brent H. Wyatt, Stephen D. Turner, Amanda J. G. Dickinson   +3 more
doaj   +1 more source

Retinobenzoic Acids and Nuclear Retinoic Acid Receptors.

Cell Structure and Function, 1991
Retinoids (retinoic acid and its analogs) are widely involved in the control of cell proliferation, cell differentiation and embryonic development. A series of potent and novel synthetic retinoids named retinobenzoic acids has been developed. Retinobenzoic acids have proven to be useful tools in the investigation of the molecular mechanisms of ...
openaire   +4 more sources

Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting via Retinoic Acid Receptor-γ*

Journal of Biological Chemistry, 2010
Alcoholism can result in fatty liver that can progress to steatohepatitis, cirrhosis, and liver cancer. Mice fed alcohol develop fatty liver through endocannabinoid activation of hepatic CB1 cannabinoid receptors (CB1R), which increases lipogenesis and ...
Bani Mukhopadhyay, Jie Liu, D. Osei-Hyiaman, G. Godlewski, P. Mukhopadhyay, Lei Wang, W. Jeong, B. Gao, G. Duester, K. Mackie, S. Kojima, G. Kunos   +11 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Regulation of FGF21 Expression and Secretion by Retinoic Acid Receptor-related Orphan Receptor α*

Journal of Biological Chemistry, 2010
Fibroblast growth factor 21 (FGF21) is a hormone produced by fat and the liver that plays an important role in lipid metabolism. FGF21 expression is induced by peroxisome proliferator-actived receptor α in response to physiological conditions requiring ...
Yongjun Wang, L. Solt, T. Burris
semanticscholar   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia.

Blood, 2010
The majority of acute promyelocytic leukemia (APL) cases are characterized by the presence of a promyelocytic leukemia-retinoic acid receptor alpha(RARA) fusion gene. In a small subset, RARA is fused to a different partner, usually involved in regulating
Yukiya Yamamoto, Sachiko Tsuzuki, M. Tsuzuki, Kousuke Handa, Y. Inaguma, N. Emi   +5 more
semanticscholar   +1 more source

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source