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Retinoic acid receptor antagonists for male contraception: current status†
Biology of Reproduction, 2020 Retinoic acid receptor alpha (RARA), a nuclear receptor protein, has been validated as a target for male contraception by gene knockout studies and also pharmacologically using a pan-retinoic acid receptor antagonist.
Md. Abdullah Al Noman +4 more
semanticscholar +1 more source
A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter [PDF]
Molecular Endocrinology, 1990 The morphogen retinoic acid (RA) regulates gene transcription by interacting with specific nuclear receptors that recognize DNA sequences near responsive promoters. While much has recently been learned about the nuclear receptor proteins, little is known about the genes that are directly regulated by RA and their cis-acting response elements recognized
Magnus Pfahl +6 more
openaire +3 more sources
Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis [PDF]
International Journal of Ophthalmology, 2015 Fungal keratitis (FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response.
Hong-Yan Zhou +5 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2003 Retinoids, a class of compounds that include retinol and its metabolite, retinoic acid, are absolutely essential for ovarian steroid production, oocyte maturation, and early embryogenesis.
Malayer Jerry +2 more
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Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. [PDF]
PLoS ONE, 2012 The retinoids, the natural or synthetic derivatives of Vitamin A (retinol), are essential for the normal development of prostate and have been shown to modulate prostate cancer progression in vivo as well as to modulate growth of several prostate cancer ...
Linda Kelsey +4 more
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Retinoic Acid Receptors and Cancer [PDF]
The Journal of Nutrition, 2002 Retinoids have been shown to inhibit the growth of many human tumor cells. Although the exact molecular mechanism of retinoid-mediated growth suppression remains known, the importance of the retinoic acid receptors (RARs) and retinoid X receptors (RXRs) has been in established a number of tumor cell models.
Dianne Robert Soprano +1 more
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Stimulation of the farnesoid X receptor promotes M2 macrophage polarization
Frontiers in Immunology, 2023 FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan +11 more
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Discover Oncology, 2023 TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong +5 more
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Neofunctionalization in Vertebrates: The Example of Retinoic Acid Receptors [PDF]
PLoS Genetics, 2006 Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies. Data on evolutionary changes in gene expression (i.e., evolution of transcription factor-cis-regulatory elements relationships) tell only part of the story; protein function, best studied by ...
Escriva, Hector +9 more
openaire +7 more sources
Maternal smoking and the retinoid pathway in the developing lung
Respiratory Research, 2012 Background Maternal smoking is a risk factor for pediatric lung disease, including asthma. Animal models suggest that maternal smoking causes defective alveolarization in the offspring.
Manoli Sara E +7 more
doaj +1 more source