Results 41 to 50 of about 146,563 (345)

Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers

Frontiers in Cell and Developmental Biology, 2023
Retinoic acid (RA) is a vital metabolite derived from vitamin A. RA plays a prominent role during development, which helps in embryological advancement and cellular differentiation.
Kousalya Lavudi, Kousalya Lavudi, Kousalya Lavudi, Shreya Madhav Nuguri, Zianne Olverson, Anantha Krishna Dhanabalan, Srinivas Patnaik, Rekha Rani Kokkanti   +7 more
doaj   +1 more source

SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma [PDF]

, 2018
Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread.
Bellenghi, Maria, Bottero, Lisabianca, Carè, Alessandra, Felicetti, Federica, Gulino, Alessandro, Mattia, Gianfranco, Petrini, Marina, Pontecorvi, Giada, Puglisi, Rossella   +8 more
core   +1 more source

2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia

Haematologica, 2019
Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu, Jin-Song Yan, Li Xia, Kang Qin, Qian-Qian Yin, Hong-Tao Xu, Meng-Qing Gao, Xiao-Ning Qu, Yu-Ting Sun, Guo-Qiang Chen   +9 more
doaj   +1 more source

Acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia accompanying ARID1B gene mutation

Hematology, 2023
In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL).
Danyang Wu, Ran Gao
doaj   +1 more source

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Nature Communications, 2017
Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and ...
Vikas Chandra, Dalei Wu, Sheng Li, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity.

PLoS ONE, 2022
The effectiveness of anthracycline chemotherapeutics (e.g., doxorubicin) is limited by anthracycline-induced cardiotoxicity (ACT). A nonsynonymous variant (S427L) in the retinoic acid receptor-γ (RARG) gene has been associated with ACT.
Jafar S Hasbullah, Erika N Scott, Amit P Bhavsar, Erandika P Gunaretnam, Fudan Miao, Hesham Soliman, Bruce C Carleton, Colin J D Ross   +7 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Retinoic Acid and Retinoid X Receptors

Cells, 2023
One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Schubert, Michael, Germain, Pierre
openaire   +4 more sources