Results 81 to 90 of about 357,868 (360)

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Genome-wide in Silico Identification of New Conserved and Functional Retinoic Acid Receptor Response Elements (Direct Repeats Separated by 5 bp)*

Journal of Biological Chemistry, 2011
Background: Retinoic acid (RA) receptors regulate gene expression through binding-specific response elements (RAREs). Results: A collection of new DR5 RAREs located ±10 kb from TSSs and conserved among 6 vertebrates species or more has been amassed ...
S. Lalevée, Yannick-Noël Anno, A. Chatagnon, É. Samarut, O. Poch, V. Laudet, G. Benoit, O. Lecompte, C. Rochette-Egly   +8 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Alitretinoin in treatment of chronic hand eczema – mechanism of action

Przegląd Dermatologiczny, 2016
Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants, often give unsatisfactory results,
Maria Matejko, Beata Kręcisz
doaj   +1 more source

Retinoic Acid Induces Neurogenesis by Activating Both Retinoic Acid Receptors (RARs) and Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ)*

Journal of Biological Chemistry, 2012
Background: RA regulates transcription through the CRABP-II/RAR and FABP5/PPARβ/δ pathways, but the contributions of these pathways to RA-induced neuronal differentiation are unknown.
Shuiliang Yu, Liraz Levi, R. Siegel, N. Noy   +3 more
semanticscholar   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt

Neural Regeneration Research, 2018
Some adult vertebrate species, such as newts, axolotls and zebrafish, have the ability to regenerate their central nervous system (CNS). However, the factors that establish a permissive CNS environment for correct morphological and functional ...
Sarah E Walker, Rachel Nottrodt, Lucas Maddalena, Christopher Carter, Gaynor E Spencer, Robert L Carlone   +5 more
doaj   +1 more source

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Advanced Science, EarlyView.
This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang, Yesheng Fu, Lihua Qiang, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu, Lingqiang Zhang   +13 more
wiley   +1 more source

Retinoic acid triazole promotes neurotrophin-mediated cell growth and proliferation in nerve cells

Bangladesh Journal of Pharmacology, 2014
In the present study, fluorophenyl retinoic acid triazole, a retinoic acid derivative having more bioavailability compared to the parent retinoic acid was investigated against cell growth and proliferation.
Hui Shi, Yan Xiao Long, Yi Zhang, Ming Zhong, Kuang Zheng   +4 more
doaj  

Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer.

Genes & Development, 2010
Retinoic acid receptor-alpha (RAR alpha) is a known estrogen target gene in breast cancer cells. The consequence of RAR alpha induction by estrogen was previously unknown.
C. Ross-Innes, R. Stark, Kelly A. Holmes, Dominic Schmidt, C. Spyrou, R. Russell, C. Massie, S. Vowler, M. Eldridge, J. Carroll   +9 more
semanticscholar   +1 more source