Results 1 to 10 of about 349,317 (300)
Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. [PDF]
Sci Adv, 2020 Functional oocytes are produced in the complete absence of retinoic acid receptors. Gametes are generated through a specialized cell differentiation process, meiosis, which, in ovaries of most mammals, is initiated during fetal life.
Vernet N +11 more
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Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy. [PDF]
Cancers (Basel), 2019 Retinoic acid (RA) signaling pathways regulate fundamental biological processes, such as cell proliferation, development, differentiation, and apoptosis. Retinoid receptors (RARs and RXRs) are ligand-dependent transcription factors.
Martino OD, Welch JS.
europepmc +2 more sources
Retinoic Acid and Its Derivatives in Skin
Cells, 2020 The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański +8 more
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The potential of retinoic acid receptors as prognostic biomarkers and therapeutic targets in gastric cancer [PDF]
Frontiers in OncologyBackgroundGastric cancer is a heterogeneous collection of tumors characterized by low survival rates. All-trans retinoic acid (retinoic-acid) is a clinically useful therapeutic agent belonging to the chemical family of retinoids, which consists of both ...
Silvio Ken Garattini +13 more
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Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers
Frontiers in Cell and Developmental Biology, 2023 Retinoic acid (RA) is a vital metabolite derived from vitamin A. RA plays a prominent role during development, which helps in embryological advancement and cellular differentiation.
Kousalya Lavudi +7 more
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Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. [PDF]
PLoS Genetics, 2013 Normal embryonic development and tissue homeostasis require precise levels of retinoic acid (RA) signaling. Despite the importance of appropriate embryonic RA signaling levels, the mechanisms underlying congenital defects due to perturbations of RA ...
Enrico D'Aniello +4 more
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Retinoic acid receptors at 35 years.
Journal of Molecular Endocrinology, 2022 For almost a century, vitamin A has been known as a nutrient critical for normal development, differentiation, and homeostasis; accordingly, there has been much interest in understanding its mechanism of action.
M. Petkovich, P. Chambon
semanticscholar +1 more source
Frontiers in Oncology, 2023 Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia (AML), 95% patients have PML-RARA fusion gene as a result of a reciprocal chromosomal translocation t(15;17)(q22; q21). The retinoic acid receptors (RARs) belong to nuclear
Wenjing Ding +13 more
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Potential Therapeutic Effect of All-Trans Retinoic Acid on Atherosclerosis
Biomolecules, 2022 Atherosclerosis is a major risk factor for myocardial infarction and ischemic stroke, which are the leading cause of death worldwide. All-trans retinoic acid (ATRA) is a natural derivative of essential vitamin A.
Qile Deng, Jixiang Chen
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Retinoic Acid and Retinoid X Receptors
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
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