Results 11 to 20 of about 349,317 (300)
Discover Oncology, 2023 TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong +5 more
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Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations.
Tapan Behl +11 more
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Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics
Cells, 2020 Autophagy is an intracellular process that targets intracellular pathogens for lysosomal degradation. Autophagy is tightly controlled at transcriptional and post-translational levels.
Prashanta Silwal +3 more
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Nutrition & Metabolism, 2023 In the last century, vitamin A was identified that included the nutritional relevant vitamin A1 / provitamin A1, as well as the vitamin A2 pathway concept.
Torsten Bohn +4 more
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International Journal of Dermatology and Venerology, 2021 . Objective:. Acne inversa is a multifactorial chronic debilitating disease. Genetic factors are involved in 40% of patients, especially the nicastrin (NCSTN) gene.
Ying-Da Wu +8 more
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Neural Regeneration Research, 2019 All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways ...
Bhaskar C Das +2 more
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CRABP proteins – relatives or homonyms?
Успехи молекулярной онкологии, 2015 Retinoic acid being the most active metabolite of vitamin A (retinol) regulates the wide spectrum of physiological processes including embryonic development, development of immune response, hematopoiesis, glucose and lipids metabolism, etc. Retinoic acid
E. M. Tchevkina, I. A. Favorskaya
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Journal of Lipid Research, 1992 In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in ...
Riaz-ul-Haq, F Chytil
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NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells. [PDF]
PLoS ONE, 2014 Acute myeloid leukemia (AML) cell lines can be driven to differentiate to monocyte-like cells by 1,25- dihydroxyvitamin D3 (1,25D) and to granulocyte-like cells by all-trans-retinoic acid (ATRA).
Elżbieta Gocek +3 more
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Thyroid hormone regulation of gene expression in primary cerebrocortical cells: role of thyroid hormone receptor subtypes and interactions with retinoic acid and glucocorticoids. [PDF]
PLoS ONE, 2014 The effects of thyroid hormone on brain development and function are largely mediated by the binding of 3,5,3'-triiodo-L-thyronine (T3) to its nuclear receptors (TR) to regulate positively or negatively gene expression.
Pilar Gil-Ibáñez +2 more
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