Results 11 to 20 of about 390,951 (380)
Neofunctionalization in vertebrates: the example of retinoic acid receptors. [PDF]
PLoS Genetics, 2006 Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies.
Hector Escriva +9 more
doaj +8 more sources
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. [PDF]
Proceedings of the National Academy of Sciences, 1993 The binding of endogenous retinoids and stereoisomers of retinoic acid (RA) to the retinoid nuclear receptors, RA receptor (RARs) and retinoid X receptors (RXRs), was characterized using nucleosol preparations from transiently transfected COS-1 cells ...
G. Allenby +10 more
semanticscholar +4 more sources
Developmental expression of retinoic acid receptors (RARs) [PDF]
Nuclear Receptor Signaling, 2009 Here, I review the developmental expression features of genes encoding the retinoic acid receptors (RARs) and the ‘retinoid X’ or rexinoid receptors (RXRs). The first detailed expression studies were performed in the mouse over two decades ago, following
P. Dollé
semanticscholar +4 more sources
The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes. [PDF]
Subcell Biochem, 2014 Epigenetics is "the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being" as defined by Conrad Waddington in 1942 in a discussion of the mechanisms of cell differentiation.
Urvalek A, Laursen KB, Gudas LJ.
europepmc +5 more sources
Discover Oncology, 2023 TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong +5 more
doaj +1 more source
Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]
, 2012 BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen +5 more
core +15 more sources
The negative side of retinoic acid receptors. [PDF]
Neurotoxicol Teratol, 2011 This is a review of research that supports a hypothesis regarding early restriction of gene expression in the vertebrate embryo. We hypothesize that vertebrate retinoic acid receptors (RARs for several vertebrates but rars for zebrafish) are part of an embryonic, epigenetic switch whose default position, at the time of fertilization is "OFF".
Linney E +3 more
europepmc +5 more sources
Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations.
Tapan Behl +11 more
doaj +1 more source
Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics
Cells, 2020 Autophagy is an intracellular process that targets intracellular pathogens for lysosomal degradation. Autophagy is tightly controlled at transcriptional and post-translational levels.
Prashanta Silwal +3 more
doaj +1 more source
International Journal of Dermatology and Venerology, 2021 . Objective:. Acne inversa is a multifactorial chronic debilitating disease. Genetic factors are involved in 40% of patients, especially the nicastrin (NCSTN) gene.
Ying-Da Wu +8 more
doaj +1 more source