Results 21 to 30 of about 349,317 (300)

Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. [PDF]

PLoS ONE, 2017
Disruption of nuclear receptors, a transcription factor superfamily regulating gene expression in animals, is one proposed mechanism through which pollution causes effects in aquatic invertebrates.
Susanne Vogeler, Tamara S Galloway, Michail Isupov, Tim P Bean   +3 more
doaj   +1 more source

Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid

Reproductive Biology and Endocrinology, 2003
Retinoids, a class of compounds that include retinol and its metabolite, retinoic acid, are absolutely essential for ovarian steroid production, oocyte maturation, and early embryogenesis.
Malayer Jerry, Thirumalapura Nagaraja, Mohan Mahesh   +2 more
doaj   +1 more source

Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism

Nuclear Receptor Research, 2015
In this overview, we provide an update on recent progress made in understanding the mechanisms of action, physiological functions, and roles in disease of retinoic acid related orphan receptors (RORs).
D. Cook, H. S. Kang, A. Jetten
semanticscholar   +1 more source

Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. [PDF]

PLoS ONE, 2011
Dominant mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of Parkinson's disease, however, little is known about the biological function of LRRK2 protein.
Cathrin Schulz, Marie Paus, Katharina Frey, Ramona Schmid, Zacharias Kohl, Detlev Mennerich, Jürgen Winkler, Frank Gillardon   +7 more
doaj   +1 more source

Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells

Journal of Lipid Research, 2004
An acidic phospholipase A2 (LPLA2) was recently purified and cloned. THP-1 cells were used to characterize the gene induction of LPLA2. THP-1 cells were stimulated with several differentiation agents.
Akira Abe, Heather K. Poucher, Miki Hiraoka, James A. Shayman   +3 more
doaj   +1 more source

Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.

PLoS ONE, 2011
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu   +8 more
doaj   +1 more source

Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis [PDF]

International Journal of Ophthalmology, 2015
Fungal keratitis (FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response.
Hong-Yan Zhou, Wei Zhong, Hong Zhang, Miao-Miao Bi, Shuang Wang, Wen-Song Zhang   +5 more
doaj   +1 more source

Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

Translational Oncology, 2021
Despite advances in personalised medicine and the emerging role of immune checkpoints in directing treatment decisions in subsets of lung cancer patients, non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related deaths worldwide.
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr   +7 more
doaj   +1 more source

In Vivo Imaging of Retinoic Acid Receptor Activity using a Sodium/Iodide Symporter and Luciferase Dual Imaging Reporter Gene

Molecular Imaging, 2004
Retinoic acids are natural derivatives of vitamin A, and play important roles in modulating tumor cell growth by regulating differentiation, thus suggesting the potential use of these derivatives in cancer therapy and prevention.
Min Kyung So, Joo Hyun Kang, June-Key Chung, Yong Jin Lee, Jae Hoon Shin, Kwang Il Kim, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee   +8 more
doaj   +1 more source

Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis

Frontiers in Oncology, 2022
Acute promyelocytic leukemia (APL) accounts for 10–15% of newly diagnosed acute myeloid leukemias (AML) and is typically caused by the fusion of promyelocytic leukemia with retinoic acid receptor α (RARA) gene.
Luca Guarnera, Tiziana Ottone, Tiziana Ottone, Emiliano Fabiani, Emiliano Fabiani, Mariadomenica Divona, Arianna Savi, Serena Travaglini, Giulia Falconi, Paola Panetta, Maria Cristina Rapanotti, Maria Cristina Rapanotti, Maria Teresa Voso, Maria Teresa Voso   +13 more
doaj   +1 more source