Recent Developments in the Optical Control of Adrenergic Signaling
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi+4 more
wiley +1 more source
Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. [PDF]
Ada Staal+10 more
openalex +1 more source
Therapeutic Potential of Retinoid X Receptor Modulators for the Treatment of the Metabolic Syndrome
The increasing prevalence of obesity is a fundamental contributor to the growing prevalence of the metabolic syndrome. Rexinoids, a class of compounds that selectively bind and activate RXR, are being studied as a potential option for the treatment of ...
Jane A. Pinaire, Anne Reifel-Miller
doaj +1 more source
Individuals of Asellus infernus, a sulfidic subterranean population of the Asellus aquaticus species complex from southeastern Romania (left) and surface individuals of A. aquaticus (right). Extreme differences in phenotype are seen comparing the subterranean and surface individuals as adults (top panels) and as embryonic samples (bottom panels ...
Haeli J. Lomheim+8 more
wiley +1 more source
Human vitamin D receptor-dependent transactivation in Saccharomyces cerevisiae requires retinoid X receptor. [PDF]
Cheng Jin, J. Wesley Pike
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Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells
An acidic phospholipase A2 (LPLA2) was recently purified and cloned. THP-1 cells were used to characterize the gene induction of LPLA2. THP-1 cells were stimulated with several differentiation agents.
Akira Abe+3 more
doaj
The Vertebral Column of Flatfish: A Review
ABSTRACT Flatfish (Pleuronectiformes) encompass fascinating fish species known for their high gastronomical value, rearing performances, and market prices, which attract both economic and scientific interest. Despite these attributes, flatfish exhibit unique morphological, developmental, and biological features, as well as distinctive swimming ...
A. M. de Azevedo+5 more
wiley +1 more source
Myocardial Retinoid X Receptor, Thyroid Hormone Receptor, and Myosin Heavy Chain Gene Expression in the Rat During Adult Aging [PDF]
Long Xu+7 more
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Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang+10 more
wiley +1 more source
Gene transcription of the retinoid X receptor α (RXRα) is regulated by fatty acids and hormones in rat hepatic cells [PDF]
Hilde Hermansen Steineger+3 more
openalex +1 more source