Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin. [PDF]
PLoS ONE, 2013 Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases.
Janine Gericke +7 more
doaj +6 more sources
Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-Synucleinopathy. [PDF]
CellsThis study investigated the therapeutic potential of the nuclear retinoid X receptor (RXR) in mitigating the progression of alpha-synucleinopathies (αSNPs), particularly in Parkinson’s disease (PD).
Zhylkibayev A +8 more
europepmc +2 more sources
AEG-1 regulates retinoid X receptor and inhibits retinoid signaling. [PDF]
Cancer Research, 2014 Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern
J. Srivastava +15 more
semanticscholar +4 more sources
Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis [PDF]
Journal of Biological Chemistry, 2000 Insulin-like growth factor-binding protein (IGFBP)-3 regulates apoptosis in an IGF-independent fashion and has been shown to localize to nuclei. We cloned the nuclear receptor retinoid X receptor-α(RXR-α) as an IGFBP-3 protein partner in a yeast two ...
Bingrong Liu +6 more
openalex +2 more sources
Journal of Lipid Research, 2013 We have established that docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, promotes survival of rat retina photoreceptors during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling ...
O. German +4 more
semanticscholar +3 more sources
Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors. [PDF]
Sci Rep, 2021 Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Upreti C +10 more
europepmc +2 more sources
Alternative retinoid X receptor (RXR) ligands
Molecular and Cellular Endocrinology, 2019 Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization with other nuclear hormone receptors (NRs), contributing thereby to activities of different signaling pathways. We review known RXR ligands as transcriptional modulators of specific RXR-dimers and the associated biological processes.
W. Krężel, R. Rühl, Á. D. De Lera
semanticscholar +5 more sources
Retinoic Acid and Retinoid X Receptors
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Schubert, Michael, Germain, Pierre
openaire +4 more sources
The retinoid X receptors and their ligands [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012 This chapter presents an overview of the current status of studies on the structural and molecular biology of the retinoid X receptor subtypes α, β, and γ (RXRs, NR2B1-3), their nuclear and cytoplasmic functions, post-transcriptional processing, and recently reported ligands.
Marcia I. Dawson, Zebin Xia
openaire +3 more sources
Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]
, 2012 BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen +5 more
core +7 more sources